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  3. TIMP3

TIMP3 (TIMP metallopeptidase inhibitor 3)

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The Function of TIMP3

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.

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Protein names

Recommended name:

Metalloproteinase inhibitor 3

Short name:

TIMP-3

Alternative name(s):

Protein MIG-5
Tissue inhibitor of metalloproteinases 3

Top Gene-Substance Interactions

TIMP3 Interacts with These Diseases

Disease Score

Substances That Increase TIMP3

Substances Interaction Organism Category

Substances That Decrease TIMP3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • AP-1
  • c-Jun
  • HNF-4alpha1
  • HNF-4alpha2
  • Sp1
  • c-Fos

Molecular Function:

  • Metal Ion Binding
  • Metalloendopeptidase Inhibitor Activity
  • Protease Binding

Biological Processes:

  • Cellular Response To Organic Substance
  • Negative Regulation Of Erk1 And Erk2 Cascade
  • Negative Regulation Of Membrane Protein Ectodomain Proteolysis
  • Negative Regulation Of Metalloendopeptidase Activity
  • Platelet Degranulation
  • Positive Regulation Of Trail-Activated Apoptotic Signaling Pathway
  • Response To Organic Substance
  • Visual Perception
  • Aging
  • Central Nervous System Development
  • Response To Amino Acid
  • Response To Estrogen
  • Response To Folic Acid
  • Response To Hormone
  • Response To Mechanical Stimulus
  • Tissue Regeneration
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| SFD| IMP-3| 21 kDa protein of extracellular matrix| Anapl_11745| AS27_11019| AS28_09205| CB1_001262006| EH28_07097| fgtimp-3| H920_10998| HSMRK222| I79_009845| K222| K222TA2| M959_14014| MDA_GLEAN10021887| Metalloproteinase inhibitor 3| metalloproteinase inhibitor 3-like protein| MIG-5 protein| N300_08608| N301_16087| N302_12654| N305_11523| N306_06443| N307_04452| N308_09984| N309_02098| N310_04519| N311_10353| N312_00932| N320_03348| N321_09103| N322_02877| N324_09496| N325_04327| N326_01124| N328_04792| N329_09870| N330_02626| N331_00984| N332_05559| N333_11182| N334_10458| N335_01707| N336_06841| N339_04351| N340_01336| N341_03341| PAL_GLEAN10015432| PANDA_010470| protein MIG-5| TIMP-3| timp3-A| TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)| tissue inhibitor metalloproteinase-3| tissue inhibitor of metalloproteinase 3| tissue inhibitor of metalloproteinase-3| tissue inhibitor of metalloproteinase 3 precursor protein| tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)| tissue inhibitor of metalloproteinases 3| UY3_09731| Y1Q_025106| Y956_12164| timp3

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