The Function of TIMP3
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
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Protein names
Recommended name:
Metalloproteinase inhibitor 3Short name:
TIMP-3Alternative name(s):
Protein MIG-5Tissue inhibitor of metalloproteinases 3
Top Gene-Substance Interactions
TIMP3 Interacts with These Diseases
| Disease | Score |
Substances That Increase TIMP3
| Substances | Interaction | Organism | Category |
Substances That Decrease TIMP3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Molecular Function:
Biological Processes:
- Cellular Response To Organic Substance
- Negative Regulation Of Erk1 And Erk2 Cascade
- Negative Regulation Of Membrane Protein Ectodomain Proteolysis
- Negative Regulation Of Metalloendopeptidase Activity
- Platelet Degranulation
- Positive Regulation Of Trail-Activated Apoptotic Signaling Pathway
- Response To Organic Substance
- Visual Perception
- Aging
- Central Nervous System Development
- Response To Amino Acid
- Response To Estrogen
- Response To Folic Acid
- Response To Hormone
- Response To Mechanical Stimulus
- Tissue Regeneration