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  3. TIMP2

TIMP2 (TIMP metallopeptidase inhibitor 2)

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The Function of TIMP2

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.

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Protein names

Recommended name:

Metalloproteinase inhibitor 2

Short name:

TIMP-2

Alternative name(s):

CSC-21K
Tissue inhibitor of metalloproteinases 2

TIMP2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2009196 (TIMP2) ??
  2. RS2277698 (TIMP2) ??
  3. RS3744790 (TIMP2) ??
  4. RS4789939 (TIMP2) ??
  5. RS9900972 (TIMP2) ??

Top Gene-Substance Interactions

TIMP2 Interacts with These Diseases

Disease Score

Substances That Increase TIMP2

Substances Interaction Organism Category

Substances That Decrease TIMP2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • c-Jun
  • C/EBPbeta
  • Sp1
  • c-Fos
  • STAT1
  • STAT1beta
  • STAT1alpha

Gene Pathways:

  • Extracellular matrix organization

Induction:

Down-regulated by TGFB1.

Molecular Function:

  • Metal Ion Binding
  • Metalloendopeptidase Inhibitor Activity
  • Protease Binding

Biological Processes:

  • Aging
  • Central Nervous System Development
  • Extracellular Matrix Disassembly
  • Negative Regulation Of Cell Proliferation
  • Negative Regulation Of Membrane Protein Ectodomain Proteolysis
  • Negative Regulation Of Mitotic Cell Cycle
  • Negative Regulation Of Ras Protein Signal Transduction
  • Positive Regulation Of Adenylate Cyclase Activity
  • Positive Regulation Of Mapk Cascade
  • Positive Regulation Of Neuron Differentiation
  • Regulation Of Rap Protein Signal Transduction
  • Response To Cytokine
  • Response To Hormone
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_07708| AS27_09304| AS28_10776| CB1_000299001| collagenase inhibitor| CSC-21K| D11Bwg1104e| D623_10019740| DDC8| EH28_16431| fgtimp-2a| H920_02899| I79_004761| M91_15862| MDA_GLEAN10004934| metalloproteinase inhibitor 2| metalloproteinase inhibitor TIMP-2| N300_05085| N301_09335| N302_09274| N303_08525| N305_07914| N307_13051| N322_08894| N331_05721| N335_09883| PAL_GLEAN10014627| PANDA_006892| testicular secretory protein Li 57| TIMP-2| timp-2a| tissue inhibitor of matrix metalloproteinase-2| tissue inhibitor of metalloproteinase 2| tissue inhibitor of metalloproteinase-2| tissue inhibitor of metalloproteinase 2a| tissue inhibitor of metalloproteinase-2a| tissue inhibitor of metalloproteinases 2| tissue inhibitor of mettaloproteinase 2| UY3_10394| Y1Q_028422| Y956_12089| timp2

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