The Function of TIMP2
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
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Protein names
Recommended name:
Metalloproteinase inhibitor 2Short name:
TIMP-2Alternative name(s):
CSC-21KTissue inhibitor of metalloproteinases 2
- RS2009196 (TIMP2) ??
- RS2277698 (TIMP2) ??
- RS3744790 (TIMP2) ??
- RS4789939 (TIMP2) ??
- RS9900972 (TIMP2) ??
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Top Gene-Substance Interactions
TIMP2 Interacts with These Diseases
| Disease | Score |
Substances That Increase TIMP2
| Substances | Interaction | Organism | Category |
Substances That Decrease TIMP2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
Down-regulated by TGFB1.
Molecular Function:
Biological Processes:
- Aging
- Central Nervous System Development
- Extracellular Matrix Disassembly
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Membrane Protein Ectodomain Proteolysis
- Negative Regulation Of Mitotic Cell Cycle
- Negative Regulation Of Ras Protein Signal Transduction
- Positive Regulation Of Adenylate Cyclase Activity
- Positive Regulation Of Mapk Cascade
- Positive Regulation Of Neuron Differentiation
- Regulation Of Rap Protein Signal Transduction
- Response To Cytokine
- Response To Hormone