• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. THBS4

THBS4 (Thrombospondin 4)

Loading...

The Function of THBS4

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Thrombospondin-4

THBS4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1866389 (THBS4) ??
  2. RS2451932 (THBS4) ??
  3. RS256438 (THBS4) ??

Top Gene-Substance Interactions

Substances That Increase THBS4

Substances Interaction Organism Category

Substances That Decrease THBS4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • C/EBPalpha
  • MEF-2A
  • NF-1
  • AREB6

Molecular Function:

  • Calcium Ion Binding
  • Heparin Binding
  • Integrin Binding

Biological Processes:

  • Behavioral Response To Pain
  • Endothelial Cell-Cell Adhesion
  • Myoblast Migration
  • Negative Regulation Of Angiogenesis
  • Positive Regulation Of Cell Division
  • Positive Regulation Of Endothelial Cell Proliferation
  • Positive Regulation Of Neutrophil Chemotaxis
  • Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
  • Regulation Of Tissue Remodeling
  • Response To Endoplasmic Reticulum Stress
  • Response To Unfolded Protein
  • Tissue Remodeling
  • Neuron Projection Morphogenesis
  • Protein Homooligomerization
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_15464| AS28_06250| CB1_000917034| D623_10035987| GW7_03372| H920_01515| I79_015624| M91_04803| M959_08793| N301_04094| N302_14997| N303_10484| N305_14708| N306_11182| N307_11850| N308_15606| N309_09216| N310_01917| N311_03887| N322_11618| N325_04182| N330_03873| N331_01237| N332_05396| N333_10222| N339_01371| N341_06910| PAL_GLEAN10024937| PANDA_004323| thbs4b| Thrombospondin-4| Thrombospondin-4-B| TREES_T100019283| TSP4| TSP-4| UY3_06304| XELAEV_18008205mg| Y1Q_024436| Y956_11451| Z169_10290| thbs4

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved