The Function of THBS4
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner.
Protein names
Recommended name:
Thrombospondin-4- RS1866389 (THBS4) ??
- RS2451932 (THBS4) ??
- RS256438 (THBS4) ??
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Top Gene-Substance Interactions
Substances That Increase THBS4
Substances | Interaction | Organism | Category |
Substances That Decrease THBS4
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Molecular Function:
Biological Processes:
- Behavioral Response To Pain
- Endothelial Cell-Cell Adhesion
- Myoblast Migration
- Negative Regulation Of Angiogenesis
- Positive Regulation Of Cell Division
- Positive Regulation Of Endothelial Cell Proliferation
- Positive Regulation Of Neutrophil Chemotaxis
- Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
- Regulation Of Tissue Remodeling
- Response To Endoplasmic Reticulum Stress
- Response To Unfolded Protein
- Tissue Remodeling
- Neuron Projection Morphogenesis
- Protein Homooligomerization