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  3. THBS1

THBS1 (Thrombospondin 1)

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The Function of THBS1

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors.

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Protein names

Recommended name:

Thrombospondin-1

THBS1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1478604 (THBS1) ??
  2. RS2228262 (THBS1) ??
  3. RS2292305 (THBS1) ??
  4. RS3743125 (THBS1) ??

Top Gene-Substance Interactions

THBS1 Interacts with These Diseases

Disease Score

Substances That Increase THBS1

Substances Interaction Organism Category

Substances That Decrease THBS1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • GR
  • GR-alpha
  • GR-beta
  • c-Jun
  • Sp1

Gene Pathways:

  • Signal Transduction
  • Metabolism of proteins
  • Hemostasis
  • TGF-beta signaling pathway
  • Extracellular matrix organization
  • p53 signaling pathway
  • Bladder cancer
  • Malaria
  • Phagosome

Molecular Function:

  • Calcium Ion Binding
  • Collagen V Binding
  • Fibrinogen Binding
  • Fibroblast Growth Factor Binding
  • Fibronectin Binding
  • Glycoprotein Binding
  • Heparin Binding
  • Identical Protein Binding
  • Integrin Binding
  • Laminin Binding
  • Low-Density Lipoprotein Particle Binding
  • Phosphatidylserine Binding
  • Proteoglycan Binding
  • Transforming Growth Factor Beta Binding

Biological Processes:

  • Activation Of Mapk Activity
  • Behavioral Response To Pain
  • Cell Adhesion
  • Cell Cycle Arrest
  • Cellular Response To Growth Factor Stimulus
  • Cellular Response To Heat
  • Cellular Response To Tumor Necrosis Factor
  • Chronic Inflammatory Response
  • Engulfment Of Apoptotic Cell
  • Extracellular Matrix Organization
  • Immune Response
  • Inflammatory Response
  • Negative Regulation Of Angiogenesis
  • Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via Mhc Class Ii
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Blood Vessel Endothelial Cell Migration
  • Negative Regulation Of Cell-Matrix Adhesion
  • Negative Regulation Of Cgmp-Mediated Signaling
  • Negative Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
  • Negative Regulation Of Dendritic Cell Antigen Processing And Presentation
  • Negative Regulation Of Endothelial Cell Chemotaxis
  • Negative Regulation Of Endothelial Cell Migration
  • Negative Regulation Of Endothelial Cell Proliferation
  • Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
  • Negative Regulation Of Fibrinolysis
  • Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
  • Negative Regulation Of Focal Adhesion Assembly
  • Negative Regulation Of Interleukin-12 Production
  • Negative Regulation Of Nitric Oxide Mediated Signal Transduction
  • Negative Regulation Of Plasma Membrane Long-Chain Fatty Acid Transport
  • Negative Regulation Of Plasminogen Activation
  • Peptide Cross-Linking
  • Platelet Degranulation
  • Positive Regulation Of Angiogenesis
  • Positive Regulation Of Blood Coagulation
  • Positive Regulation Of Blood Vessel Endothelial Cell Migration
  • Positive Regulation Of Cell Migration
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Chemotaxis
  • Positive Regulation Of Endothelial Cell Apoptotic Process
  • Positive Regulation Of Endothelial Cell Migration
  • Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
  • Positive Regulation Of Fibroblast Migration
  • Positive Regulation Of Macrophage Activation
  • Positive Regulation Of Macrophage Chemotaxis
  • Positive Regulation Of Phosphorylation
  • Positive Regulation Of Protein Kinase B Signaling
  • Positive Regulation Of Reactive Oxygen Species Metabolic Process
  • Positive Regulation Of Smooth Muscle Cell Proliferation
  • Positive Regulation Of Transforming Growth Factor Beta1 Production
  • Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
  • Positive Regulation Of Translation
  • Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process
  • Protein O-Linked Fucosylation
  • Regulation Of Cgmp Metabolic Process
  • Response To Calcium Ion
  • Response To Endoplasmic Reticulum Stress
  • Response To Glucose
  • Response To Hypoxia
  • Response To Magnesium Ion
  • Response To Mechanical Stimulus
  • Response To Progesterone
  • Response To Testosterone
  • Response To Unfolded Protein
  • Sprouting Angiogenesis
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| TSP1| AS27_09352| AS28_07383| D623_10023785| H920_05534| I79_010214| M91_12734| M959_13280| N300_01993| N301_08578| N302_01699| N303_07104| N305_09597| N306_10793| N308_04674| N309_14642| N310_13125| N311_06591| N312_01584| N320_06067| N321_04885| N322_06646| N325_03294| N326_03987| N327_08819| N328_10000| N329_12303| N330_07037| N331_00125| N332_12039| N334_05817| N335_09544| N336_09627| N339_12120| N340_10012| N341_03873| PAL_GLEAN10023633| PANDA_001089| tbsp1| THBS| THBS-1| Thrombospondin-1| thrombospondin-1b| thrombospondin-1p180| thrombospondin-p50| TREES_T100000956| TSP| tsp-1| UY3_16172| Y1Q_024486| Y956_16527| Z169_03947| thbs1

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