The Function of THBS1
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors.
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Protein names
Recommended name:
Thrombospondin-1- RS1478604 (THBS1) ??
- RS2228262 (THBS1) ??
- RS2292305 (THBS1) ??
- RS3743125 (THBS1) ??
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Top Gene-Substance Interactions
THBS1 Interacts with These Diseases
| Disease | Score |
Substances That Increase THBS1
| Substances | Interaction | Organism | Category |
Substances That Decrease THBS1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Phosphatidylserine Binding
- Glycoprotein Binding
- Fibronectin Binding
- Integrin Binding
- Calcium Ion Binding
- Heparin Binding
- Fibroblast Growth Factor Binding
- Low-Density Lipoprotein Particle Binding
- Identical Protein Binding
- Laminin Binding
- Proteoglycan Binding
- Transforming Growth Factor Beta Binding
- Fibrinogen Binding
- Collagen V Binding
Biological Processes:
- Activation Of Mapk Activity
- Response To Hypoxia
- Negative Regulation Of Endothelial Cell Proliferation
- Negative Regulation Of Cell-Matrix Adhesion
- Sprouting Angiogenesis
- Chronic Inflammatory Response
- Platelet Degranulation
- Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via Mhc Class Ii
- Negative Regulation Of Dendritic Cell Antigen Processing And Presentation
- Inflammatory Response
- Immune Response
- Response To Unfolded Protein
- Cell Cycle Arrest
- Cell Adhesion
- Positive Regulation Of Cell Proliferation
- Response To Mechanical Stimulus
- Response To Glucose
- Positive Regulation Of Endothelial Cell Migration
- Negative Regulation Of Endothelial Cell Migration
- Negative Regulation Of Plasma Membrane Long-Chain Fatty Acid Transport
- Negative Regulation Of Nitric Oxide Mediated Signal Transduction
- Negative Regulation Of Cgmp-Mediated Signaling
- Negative Regulation Of Plasminogen Activation
- Positive Regulation Of Macrophage Chemotaxis
- Positive Regulation Of Fibroblast Migration
- Negative Regulation Of Angiogenesis
- Peptide Cross-Linking
- Positive Regulation Of Blood Coagulation
- Extracellular Matrix Organization
- Positive Regulation Of Cell Migration
- Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
- Regulation Of Cgmp Metabolic Process
- Response To Magnesium Ion
- Response To Progesterone
- Negative Regulation Of Interleukin-12 Production
- Positive Regulation Of Transforming Growth Factor Beta1 Production
- Response To Testosterone
- Cellular Response To Heat
- Response To Endoplasmic Reticulum Stress
- Protein O-Linked Fucosylation
- Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
- Positive Regulation Of Phosphorylation
- Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process
- Positive Regulation Of Macrophage Activation
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Positive Regulation Of Blood Vessel Endothelial Cell Migration
- Negative Regulation Of Blood Vessel Endothelial Cell Migration
- Engulfment Of Apoptotic Cell
- Positive Regulation Of Translation
- Positive Regulation Of Angiogenesis
- Behavioral Response To Pain
- Positive Regulation Of Smooth Muscle Cell Proliferation
- Positive Regulation Of Chemotaxis
- Response To Calcium Ion
- Negative Regulation Of Focal Adhesion Assembly
- Positive Regulation Of Protein Kinase B Signaling
- Negative Regulation Of Fibrinolysis
- Cellular Response To Tumor Necrosis Factor
- Cellular Response To Growth Factor Stimulus
- Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
- Positive Regulation Of Endothelial Cell Apoptotic Process
- Positive Regulation Of Reactive Oxygen Species Metabolic Process
- Negative Regulation Of Endothelial Cell Chemotaxis
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway