The Function of THBD
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Protein names
Recommended name:
ThrombomodulinShort name:
TMAlternative name(s):
FetomodulinCD antigen CD141
- RS1042579 (THBD) ??
- RS1042580 (THBD) ??
- RS1800576 (THBD) ??
- RS3176123 (THBD) ??
- RS3176130 (THBD) ??
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Top Gene-Substance Interactions
THBD Interacts with These Diseases
| Disease | Score |
Substances That Increase THBD
| Substances | Interaction | Organism | Category |
Substances That Decrease THBD
| Substances | Interaction | Organism | Category |
Advanced Summary
Covered on Genetics Home Reference: atypical hemolytic-uremic syndromeFrom NCBI Gene: Atypical hemolytic-uremic syndrome 6Thrombophilia due to thrombomodulin defectFrom UniProt: Thrombophilia due to thrombomodulin defect (THPH12): A hemostatic disorder characterized by a tendency to thrombosis. [MIM:614486] Hemolytic uremic syndrome atypical 6 (AHUS6): An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. [MIM:612926]
From NCBI Gene: The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008] From UniProt: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Endothelial cells are unique in synthesizing thrombomodulin.
Gene Pathways:
Molecular Function:
Biological Processes:
- Female Pregnancy
- Blood Coagulation
- Response To X-Ray
- Negative Regulation Of Platelet Activation
- Negative Regulation Of Blood Coagulation
- Response To Lipopolysaccharide
- Leukocyte Migration
- Response To Camp
- Negative Regulation Of Fibrinolysis
Drug Bank:
- Drotrecogin Alfa
- Ibuprofen