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  3. TGM3

TGM3 (Transglutaminase 3)

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The Function of TGM3

Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath.

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Protein names

Recommended name:

Protein-glutamine gamma-glutamyltransferase E

Short name:

TGE

Alternative name(s):

Transglutaminase E
TG(E
TGase E
Transglutaminase-3
TGase-3

TGM3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1012621 (TGM3) ??
  2. RS214782 (TGM3) ??

Top Gene-Substance Interactions

Substances That Increase TGM3

Substances Interaction Organism Category

Substances That Decrease TGM3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Max

Cofactor:

Binds 3 Ca(2+) cations per subunit. Binds 1 Ca(2+) as a zymogen, and binds 2 more Ca(2+) cations, or other divalent metal cations, after proteolytic processing.

Molecular Function:

  • Calcium Ion Binding
  • Catalytic Activity
  • Protein-Glutamine Gamma-Glutamyltransferase Activity
  • Transferase Activity, Transferring Acyl Groups

Biological Processes:

  • Cell Envelope Organization
  • Cellular Protein Modification Process
  • Hair Follicle Morphogenesis
  • Keratinization
  • Keratinocyte Differentiation
  • Peptide Cross-Linking
  • Protein Tetramerization

Drug Bank:

  • L-Glutamine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| protein-glutamine-gamma-glutamyltransferase| CB1_000951076| D623_10032384| E polypeptide| E polypeptide, protein-glutamine-gamma-glutamyltransferase| glutamine gamma-glutamyltransferase E| H920_18089| M91_19720| MDA_GLEAN10024988| N320_10215| N322_11293| N327_10312| N329_05779| N331_04772| N332_07792| N334_11767| N335_12464| N336_04682| N339_00714| N340_07585| PAL_GLEAN10024154| PANDA_007379| protein-glutamine gamma-glutamyltransferase E| RGD1561831| TGase-3| TGase E| TGE| TG E| TG(E)| transglutaminase-3| transglutaminase 3, E polypeptide| transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)| transglutaminase E| TREES_T100018108| UY3_14603| we| tgm3

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