The Function of TGM3
Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath.
Protein names
Recommended name:
Protein-glutamine gamma-glutamyltransferase EShort name:
TGEAlternative name(s):
Transglutaminase ETG(E
TGase E
Transglutaminase-3
TGase-3
- RS1012621 (TGM3) ??
- RS214782 (TGM3) ??
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Top Gene-Substance Interactions
Substances That Increase TGM3
| Substances | Interaction | Organism | Category |
Substances That Decrease TGM3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Cofactor:
Binds 3 Ca(2+) cations per subunit. Binds 1 Ca(2+) as a zymogen, and binds 2 more Ca(2+) cations, or other divalent metal cations, after proteolytic processing.
Molecular Function:
- Calcium Ion Binding
- Catalytic Activity
- Protein-Glutamine Gamma-Glutamyltransferase Activity
- Transferase Activity, Transferring Acyl Groups
Biological Processes:
- Cell Envelope Organization
- Cellular Protein Modification Process
- Hair Follicle Morphogenesis
- Keratinization
- Keratinocyte Differentiation
- Peptide Cross-Linking
- Protein Tetramerization
Drug Bank:
- L-Glutamine