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  3. TGIF1

TGIF1 (TGFB induced factor homeobox 1)

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The Function of TGIF1

Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.

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Protein names

Recommended name:

Homeobox protein TGIF1

Alternative name(s):

5'-TG-3'-interacting factor 1

TGIF1 SNPs

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  1. RS12457997 (TGIF1) ??

Top Gene-Substance Interactions

TGIF1 Interacts with These Diseases

Disease Score

Substances That Increase TGIF1

Substances Interaction Organism Category

Substances That Decrease TGIF1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CUTL1
  • AP-1
  • c-Jun
  • c-Fos
  • FOXF2
  • E47
  • Hand1

Gene Pathways:

  • Disease
  • Signal Transduction
  • Gene Expression

Molecular Function:

  • Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
  • Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcription Corepressor Activity
  • Transcription Factor Activity, Sequence-Specific Dna Binding

Biological Processes:

  • Cellular Response To Growth Factor Stimulus
  • Multicellular Organism Development
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Transcription, Dna-Templated
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 5'-TG-3'-interacting factor 1| A306_09656| AS27_05820| AS28_06294| avian knotted-related protein| CB1_002807003| D623_10019916| EH28_04558| fa06h05| fb33g11| H920_11501| Homeobox protein AKR| homeobox protein TGIF1| homeobox protein TGIF1-like protein| homeodomain protein AKR| HPE4| M959_00981| MDA_GLEAN10025284| N300_05327| N301_04842| N302_01025| N303_01578| N305_03477| N306_04850| N308_00748| N309_08161| N310_02739| N311_08158| N312_06043| N320_00908| N321_10242| N322_05615| N324_08389| N325_03653| N326_07858| N327_04827| N328_04969| N329_04148| N332_08045| N333_06710| N334_10233| N335_12186| N336_04955| N339_10606| N340_00378| N341_10289| PANDA_017378| TALE family homeobox| TALE homeobox TG-interacting factor| Tfig| TGFB-induced factor homeobox 1| TGFB-induced factor (TALE family homeobox)| Tgif| TG interacting factor| TG-interacting factor| TG interacting factor 1| TG-interacting homeobox protein| transforming growth factor-beta-induced factor| transforming growth factor-beta-induced factor 1| TREES_T100013879| Y1Q_015173| Y956_15446| Z169_12373| tgif1

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