The Function of TFDP2
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).
Protein names
Recommended name:
Transcription factor Dp-2Alternative name(s):
E2F dimerization partner 2- RS347685 (TFDP2) ??
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Top Gene-Substance Interactions
Substances That Increase TFDP2
| Substances | Interaction | Organism | Category |
Substances That Decrease TFDP2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
High levels in heart and skeletal muscle. Also found in placenta, kidney, brain, lung and liver. The presence as well as the abundance of the different transcripts appear to vary significantly in different tissues and cell lines.
Gene Pathways:
Molecular Function:
- Dna Binding
- Protein Domain Specific Binding
- Rna Polymerase Ii Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Cofactor Activity
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Factor Binding
Biological Processes:
- Dna Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
- Heart Development
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Transcription From Rna Polymerase Ii Promoter
- Transcription, Dna-Templated