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  3. TFDP2

TFDP2 (Transcription factor Dp-2)

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The Function of TFDP2

Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).

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Protein names

Recommended name:

Transcription factor Dp-2

Alternative name(s):

E2F dimerization partner 2

TFDP2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS347685 (TFDP2) ??

Top Gene-Substance Interactions

Substances That Increase TFDP2

Substances Interaction Organism Category

Substances That Decrease TFDP2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53

Tissue specificity:

High levels in heart and skeletal muscle. Also found in placenta, kidney, brain, lung and liver. The presence as well as the abundance of the different transcripts appear to vary significantly in different tissues and cell lines.

Gene Pathways:

  • Disease
  • Signal Transduction
  • Gene Expression

Molecular Function:

  • Dna Binding
  • Protein Domain Specific Binding
  • Rna Polymerase Ii Transcription Factor Activity, Sequence-Specific Dna Binding
  • Transcription Cofactor Activity
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Transcription Factor Binding

Biological Processes:

  • Dna Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
  • Heart Development
  • Negative Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Transcription, Dna-Templated
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| dp2| A306_05069| AS27_04137| AS28_03046| CB1_001390016| dp-2| DP3| DP-3| E2F dimerization partner 2| H920_16749| M91_12300| M959_04777| MDA_GLEAN10023788| N300_01925| N301_14064| N302_05911| N303_02437| N305_11347| N306_07968| N307_08146| N308_11730| N309_03420| N310_10735| N312_08171| N320_11796| N321_09621| N322_07961| N325_05466| N326_13212| N327_05831| N328_02630| N329_02964| N331_01624| N332_07722| N333_09645| N334_09523| N335_08442| N336_00581| N339_03832| N340_11135| N341_06159| PAL_GLEAN10015906| PANDA_005038| Tcfdp2| transcription factor Dp 2| transcription factor Dp-2 (E2F dimerization partner 2)| transcription factor Dp-2 (E2F dimerization partner 2) isoform A| transcription factor Dp-2 (E2F dimerization partner 2) isoform B| transcription factor Dp-2 (E2F dimerization partner 2) isoform C| Transcription factor Dp-2 isoform 1-like protein| transcription factor Dp-2-like protein| TREES_T100011109| Y1Q_028295| Y956_12974| Z169_10320| tfdp2

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