The Function of TFAP2C
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
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Protein names
Recommended name:
Transcription factor AP-2 gammaAlternative name(s):
AP2-gammaActivating enhancer-binding protein 2 gamma
Transcription factor ERF-1
- RS6092354 (TFAP2C) ??
- RS6099314 (TFAP2C) ??
- RS6127813 (TFAP2C) ??
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Top Gene-Substance Interactions
TFAP2C Interacts with These Diseases
| Disease | Score |
Substances That Increase TFAP2C
| Substances | Interaction | Organism | Category |
Substances That Decrease TFAP2C
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Induction:
During retinoic acid-mediated differentiation.
Molecular Function:
- Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
- Core Promoter Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Dna Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Protein Dimerization Activity
Biological Processes:
- Regulation Of Transcription From Rna Polymerase Ii Promoter
- Cell-Cell Signaling
- Male Gonad Development
- Regulation Of Gene Expression, Epigenetic
- Regulation Of Cell Proliferation
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter