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  3. TFAP2C

TFAP2C (Transcription factor AP-2 gamma)

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The Function of TFAP2C

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

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Protein names

Recommended name:

Transcription factor AP-2 gamma

Alternative name(s):

AP2-gamma
Activating enhancer-binding protein 2 gamma
Transcription factor ERF-1

TFAP2C SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS6092354 (TFAP2C) ??
  2. RS6099314 (TFAP2C) ??
  3. RS6127813 (TFAP2C) ??

Top Gene-Substance Interactions

TFAP2C Interacts with These Diseases

Disease Score

Substances That Increase TFAP2C

Substances Interaction Organism Category

Substances That Decrease TFAP2C

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • ER-alpha
  • p53
  • AP-2gamma
  • c-Myb

Induction:

During retinoic acid-mediated differentiation.

Molecular Function:

  • Core Promoter Binding
  • Dna Binding
  • Protein Dimerization Activity
  • Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding

Biological Processes:

  • Cell-Cell Signaling
  • Male Gonad Development
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of Cell Proliferation
  • Regulation Of Gene Expression, Epigenetic
  • Regulation Of Transcription From Rna Polymerase Ii Promoter
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ERF1| activating enhancer binding protein 2 gamma| activating enhancer-binding protein 2 gamma| activator protein 2 gamma| Ap-2.2| ap-2g| AP2gamma| AP2-GAMMA| AS27_03214| AS28_06976| CB1_000875032| D623_10013760| EGK_02266| estrogen receptor factor 1| fb48g05| fb49c04| H920_07272| hAP-2g| I79_007847| M959_06538| MDA_GLEAN10009915| N300_15749| N301_06109| N302_00401| N303_02892| N305_13227| N306_01696| N307_09867| N308_06826| N309_11717| N310_00777| N320_09327| N321_04170| N322_01166| N324_05162| N326_03601| N329_09662| N330_04993| N331_10290| N332_00384| N333_06739| N340_04333| N341_04327| PAL_GLEAN10024529| PANDA_010143| stimulated by retinoic acid gene 2| Stra2| Tcfap2c| tfa2pc| TFAP2G| tfap2gamma| transcription factor AP-2, gamma| transcription factor AP-2 gamma (activating enhancer binding pro| transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)| transcription factor AP-2 gamma (activating enhancer-binding protein 2 gamma)| transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) isoform A| transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) isoform B| transcription factor ERF-1| TREES_T100015614| UY3_07026| Y1Q_009226| Y956_12873| Z169_03694| tfap2c

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