The Function of TFAP2A
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.
Protein names
Recommended name:
Transcription factor AP-2-alphaShort name:
AP-2Alternative name(s):
AP2-alphaAP-2 transcription factor
Activating enhancer-binding protein 2-alpha
Activator protein 2
- RS2149150 (TFAP2A) ??
- RS2876167 (TFAP2A) ??
- RS3798696 (TFAP2A) ??
- RS855250 (TFAP2A) ??
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Top Gene-Substance Interactions
TFAP2A Interacts with These Diseases
Disease | Score |
Substances That Increase TFAP2A
Substances | Interaction | Organism | Category |
Substances That Decrease TFAP2A
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Molecular Function:
- Chromatin Binding
- Core Promoter Proximal Region Sequence-Specific Dna Binding
- Protein Dimerization Activity
- Protein Homodimerization Activity
- Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Core Promoter Sequence-Specific Dna Binding
- Rna Polymerase Ii Transcription Factor Activity, Sequence-Specific Dna Binding
- Sequence-Specific Dna Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcription Coactivator Activity
- Transcription Factor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcription Regulatory Region Dna Binding
- Transcription Regulatory Region Sequence-Specific Dna Binding
Biological Processes:
- Bone Morphogenesis
- Cellular Response To Iron Ion
- Embryonic Cranial Skeleton Morphogenesis
- Embryonic Forelimb Morphogenesis
- Eyelid Development In Camera-Type Eye
- Inner Ear Morphogenesis
- Kidney Development
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Reactive Oxygen Species Metabolic Process
- Negative Regulation Of Transcription, Dna-Templated
- Negative Regulation Of Transcription By Competitive Promoter Binding
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Oculomotor Nerve Formation
- Optic Cup Structural Organization
- Optic Vesicle Morphogenesis
- Palate Development
- Positive Regulation Of Bone Mineralization
- Positive Regulation Of Gene Expression
- Positive Regulation Of Neuron Apoptotic Process
- Positive Regulation Of Tooth Mineralization
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Cell Differentiation
- Retina Layer Formation
- Sensory Perception Of Sound
- Trigeminal Nerve Development
- Response To Lipopolysaccharide
- Response To Water Deprivation
- Schwann Cell Development