The Function of TFAP2A
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.
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Protein names
Recommended name:
Transcription factor AP-2-alphaShort name:
AP-2Alternative name(s):
AP2-alphaAP-2 transcription factor
Activating enhancer-binding protein 2-alpha
Activator protein 2
- RS2149150 (TFAP2A) ??
- RS2876167 (TFAP2A) ??
- RS3798696 (TFAP2A) ??
- RS855250 (TFAP2A) ??
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Top Gene-Substance Interactions
TFAP2A Interacts with These Diseases
| Disease | Score |
Substances That Increase TFAP2A
| Substances | Interaction | Organism | Category |
Substances That Decrease TFAP2A
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Molecular Function:
- Transcription Regulatory Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Core Promoter Sequence-Specific Dna Binding
- Rna Polymerase Ii Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Factor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Core Promoter Proximal Region Sequence-Specific Dna Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Chromatin Binding
- Transcription Coactivator Activity
- Protein Homodimerization Activity
- Sequence-Specific Dna Binding
- Transcription Regulatory Region Dna Binding
- Protein Dimerization Activity
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Kidney Development
- Optic Vesicle Morphogenesis
- Optic Cup Structural Organization
- Sensory Perception Of Sound
- Negative Regulation Of Cell Proliferation
- Response To Water Deprivation
- Positive Regulation Of Gene Expression
- Retina Layer Formation
- Negative Regulation Of Transcription By Competitive Promoter Binding
- Schwann Cell Development
- Trigeminal Nerve Development
- Oculomotor Nerve Formation
- Positive Regulation Of Bone Mineralization
- Response To Lipopolysaccharide
- Embryonic Forelimb Morphogenesis
- Inner Ear Morphogenesis
- Negative Regulation Of Apoptotic Process
- Positive Regulation Of Neuron Apoptotic Process
- Regulation Of Cell Differentiation
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Embryonic Cranial Skeleton Morphogenesis
- Palate Development
- Bone Morphogenesis
- Eyelid Development In Camera-Type Eye
- Positive Regulation Of Tooth Mineralization
- Cellular Response To Iron Ion
- Negative Regulation Of Reactive Oxygen Species Metabolic Process