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  3. TET2

TET2 (Tet methylcytosine dioxygenase 2)

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The Function of TET2

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.

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Protein names

Recommended name:

Methylcytosine dioxygenase TET2

TET2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10010325 (TET2) ??
  2. RS11605083 (TET2) ??
  3. RS1541374 (TET2) ??
  4. RS17035310 (TET2) ??
  5. RS2189234 (TET2) ??
  6. RS2454206 (TET2) ??
  7. RS290258 (TET2) ??
  8. RS4698934 (TET2) ??
  9. RS5751168 (TET2) ??
  10. RS6855629 (TET2) ??
  11. RS7679673 (TET2) ??
  12. RS9790517 (TET2) ??

Top Gene-Substance Interactions

TET2 Interacts with These Diseases

Disease Score

Substances That Increase TET2

Substances Interaction Organism Category

Substances That Decrease TET2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • HNF-1A
  • HNF-1
  • c-Myc
  • YY1
  • USF1

Tissue specificity:

Broadly expressed. Highly expressed in hematopoietic cells; highest expression observed in granulocytes. Expression is reduced in granulocytes from peripheral blood of patients affected by myelodysplastic syndromes.

Gene Pathways:

  • Gene Expression

Caution:

Subsequent steps in cytosine demethylation are subject to discussion. According to a first model cytosine demethylation occurs through deamination of 5hmC into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. According to another model, cytosine demethylation is rather mediated via conversion of 5hmC into 5fC and 5caC, followed by excision by TDG (PubMed:21817016).

Cofactor:

Binds 3 zinc ions per subunit. The zinc ions have a structural role (PubMed:24315485).

Molecular Function:

  • 2,4-Dichlorophenoxyacetate Alpha-Ketoglutarate Dioxygenase Activity
  • C-19 Gibberellin 2-Beta-Dioxygenase Activity
  • C-20 Gibberellin 2-Beta-Dioxygenase Activity
  • Dna Binding
  • Dna-N1-Methyladenine Dioxygenase Activity
  • Ferrous Iron Binding
  • Hypophosphite Dioxygenase Activity
  • Methylcytosine Dioxygenase Activity
  • Procollagen-Proline Dioxygenase Activity
  • Sulfonate Dioxygenase Activity
  • Zinc Ion Binding

Biological Processes:

  • 5-Methylcytosine Catabolic Process
  • Cell Cycle
  • Cytosine Metabolic Process
  • Dna Demethylation
  • Hematopoietic Stem Cell Homeostasis
  • Hemoglobin Metabolic Process
  • Histone H3-K4 Trimethylation
  • Kidney Development
  • Liver Morphogenesis
  • Myeloid Cell Differentiation
  • Myeloid Progenitor Cell Differentiation
  • Oxidative Demethylation
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Post-Embryonic Development
  • Protein O-Linked Glycosylation
  • Response To Organic Cyclic Compound
  • Spleen Development
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| MDS| A306_15873| Anapl_16400| AS27_15594| AS28_14638| Ayu17-449| CB1_000750003| D623_10030624| GW7_12531| H920_12780| KIAA1546| M959_04164| methylcytosine dioxygenase| methylcytosine dioxygenase TET2| methylcytosine dioxygenase TET2-like protein| N300_08671| N301_12580| N302_04237| N303_01872| N305_00574| N306_13831| N307_06804| N308_06619| N309_03508| N310_09151| N311_07078| N312_12894| N320_01163| N321_12837| N322_01026| N324_11706| N325_10379| N327_13674| N328_08916| N329_06105| N330_04341| N332_08854| N333_07622| N334_01299| N335_12956| N336_01548| N339_07897| N340_12248| PAL_GLEAN10022583| PANDA_016408| probable methylcytosine dioxygenase TET2| Protein TET2| putative methylcytosine dioxygenase TET2| RGD1311625| ten-eleven-translocation 2| TET1| tet oncogene 2| tet oncogene family member 2| tet oncoprotein family member 2| TREES_T100004034| UY3_01899| Y1Q_024336| Y956_00935| Z169_13773| tet2

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