TCF7L2 | SelfDecode | Genome Analysis

Summary of TCF7L2

TCF7L2 is implicated in a large variety of diseases, especially type 2 diabetes. This is mediated by impaired insulin secretion and reduced GLP-1 activation.

TCF7L2 is a transcription factor that influences the transcription of several genes. It has many functions within the cell [R].

It plays a key role in the Wnt signaling pathway. The protein is important for blood glucose homeostasis, and it is associated with increased rates of type 2 diabetes [R].

Variants in TCF7L2 may be associated with colorectal cancer [R].

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The Function of TCF7L2

Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.

Protein names

Recommended name:

Transcription factor 7-like 2

Short name:

TCF-4

Alternative name(s):

HMG box transcription factor 4
T-cell-specific transcription factor 4
T-cell factor 4
hTCF-4

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Top Gene-Substance Interactions

TCF7L2 Interacts with These Diseases

Disease	Score

Fixes

FIX: Inositol (R), GLP-1 Activators will help counteract this gene.

Substances That Increase TCF7L2

Category:

Substances	Interaction	Organism	Category

Substances That Decrease TCF7L2

Category:

Substances	Interaction	Organism	Category

Conditions with Increased Gene Activity

Experimental Variables:

Condition	Change (log₂fold)	Comparison	Species	Experimental variables	Experiment name

Conditions with Decreased Gene Activity

Experimental Variables:

Condition	Change (log₂fold)	Comparison	Species	Experimental variables	Experiment name

Technical

The following transcription factors affect gene expression:

Tissue specificity:

Detected in epithelium from small intestine, with the highest expression at the top of the crypts and a gradient of expression from crypt to villus. Detected in colon epithelium and colon cancer, and in epithelium from mammary gland and carcinomas derived therefrom.

Gene Pathways:

Developmental stage:

Highly expressed in crypt regions and barely detectable in villi in epithelium from fetal small intestine at week 16. At week 22 expression in villi had increased strongly.

Molecular Function:

Biological Processes:

*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| TCF-4| transcription factor 7-like 2 (T-cell specific, HMG-box)| tcf4| A306_04167| AS27_02771| AS28_09774| CB1_000678036| D623_10027938| HMG-box containing TCF4| HMG box transcription factor 4| HMG box transcription factor TCF7L2| hTCF-4| I79_020783| M91_09909| M959_11510| N300_04613| N301_07045| N302_14613| N303_05182| N305_10793| N306_13968| N307_08843| N312_06765| N324_06883| N325_08860| N327_03024| N329_02451| N330_03280| N332_06180| N333_07587| N334_04570| N335_11645| N336_04660| N340_08457| N341_04776| PAL_GLEAN10014178| PANDA_001414| PsTCF4| T-cell factor 4| T-cell factor-4 variant A| T-cell factor-4 variant B| T-cell factor-4 variant C| T-cell factor-4 variant D| T-cell factor-4 variant E| T-cell factor-4 variant F| T-cell factor-4 variant G| T-cell factor-4 variant H| T-cell factor-4 variant I| T-cell factor-4 variant J| T-cell factor-4 variant K| T-cell factor-4 variant L| T-cell factor-4 variant M| T-cell factor-4 variant X2| T-cell-specific transcription factor 4| TCF4B| TCF4E| TCFL2| transcription factor 7-like 2| transcription factor 7-like 2 protein| transcription factor 7-like 2 pseudogene| transcription factor 7 like 2, T cell specific, HMG box| transcription factor 7-like 2 (T-cell specific, HMG-box) isoform A| transcription factor 7-like 2 (T-cell specific, HMG-box) isoform B| transcription factor 7-like 2 (T-cell specific, HMG-box) isoform C| transcription factor 7-like 2 (T-cell specific, HMG-box) isoform D| transcription factor 7-like 2 (T-cell specific, HMG-box) isoform E| transcription factor 7-like 2 (T-cell specific, HMG-box) isoform F| transcription factor Tcf4| TREES_T100003497| UY3_03764| XTCF-4| Y1Q_002643| Y956_01364| Z169_15483| tcf7l2

TCF7L2 (Transcription factor 7 like 2)

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