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  3. TCF7L2

TCF7L2 (Transcription factor 7 like 2)

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Summary of TCF7L2

TCF7L2 is implicated in a large variety of diseases, especially type 2 diabetes. This is mediated by impaired insulin secretion and reduced GLP-1 activation.

TCF7L2 is a transcription factor that influences the transcription of several genes. It has many functions within the cell [R]. 

It plays a key role in the Wnt signaling pathway. The protein is important for blood glucose homeostasis, and it is associated with increased rates of type 2 diabetes [R].

Variants in TCF7L2 may be associated with colorectal cancer [R].

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The Function of TCF7L2

Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.

Protein names

Recommended name:

Transcription factor 7-like 2

Short name:

TCF-4

Alternative name(s):

HMG box transcription factor 4
T-cell-specific transcription factor 4
T-cell factor 4
hTCF-4

TCF7L2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10749127 (TCF7L2) ??
  2. RS10885406 (TCF7L2) ??
  3. RS11196172 (TCF7L2) ??
  4. RS11196174 (TCF7L2) ??
  5. RS11196205 (TCF7L2) ??
  6. RS11196218 (TCF7L2) ??
  7. RS12243326 (TCF7L2) ??
  8. RS12255372 (TCF7L2) ??
  9. RS12772424 (TCF7L2) ??
  10. RS290475 (TCF7L2) ??
  11. RS290481 (TCF7L2) ??
  12. RS290487 (TCF7L2) ??
  13. RS290489 (TCF7L2) ??
  14. RS34872471 (TCF7L2) ??
  15. RS4132670 (TCF7L2) ??
  16. RS4506565 (TCF7L2) ??
  17. RS4918796 (TCF7L2) ??
  18. RS74157220 (TCF7L2) ??
  19. RS7895340 (TCF7L2) ??
  20. RS7901695 (TCF7L2) ??
  21. RS7903146 (TCF7L2) ??
  22. RS7904519 (TCF7L2) ??
  23. RS7917983 (TCF7L2) ??

Top Gene-Substance Interactions

TCF7L2 Interacts with These Diseases

Disease Score

Fixes

FIX: Inositol (R), GLP-1 Activators will help counteract this gene.

Substances That Increase TCF7L2

Substances Interaction Organism Category

Substances That Decrease TCF7L2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • p53
  • NF-kappaB1
  • HNF-4alpha1
  • HNF-4alpha2
  • c-Myc
  • USF1
  • USF-1

Tissue specificity:

Detected in epithelium from small intestine, with the highest expression at the top of the crypts and a gradient of expression from crypt to villus. Detected in colon epithelium and colon cancer, and in epithelium from mammary gland and carcinomas derived therefrom.

Gene Pathways:

  • Disease
  • Pathways in cancer
  • Signal Transduction
  • Basal cell carcinoma
  • Melanogenesis
  • Wnt signaling pathway
  • Adherens junction
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC)
  • Colorectal cancer
  • Endometrial cancer
  • Prostate cancer
  • Thyroid cancer
  • Acute myeloid leukemia

Developmental stage:

Highly expressed in crypt regions and barely detectable in villi in epithelium from fetal small intestine at week 16. At week 22 expression in villi had increased strongly.

Molecular Function:

  • Armadillo Repeat Domain Binding
  • Beta-Catenin Binding
  • Gamma-Catenin Binding
  • Nuclear Hormone Receptor Binding
  • Protein Kinase Binding
  • Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
  • Rna Polymerase Ii Repressing Transcription Factor Binding
  • Sequence-Specific Dna Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Transcription Factor Binding
  • Transcription Regulatory Region Dna Binding

Biological Processes:

  • Beta-Catenin-Tcf Complex Assembly
  • Blood Vessel Development
  • Canonical Wnt Signaling Pathway
  • Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
  • Cell Cycle Arrest
  • Cell Proliferation
  • Fat Cell Differentiation
  • Glucose Homeostasis
  • Maintenance Of Dna Repeat Elements
  • Myoblast Fate Commitment
  • Negative Regulation Of Canonical Wnt Signaling Pathway
  • Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
  • Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
  • Negative Regulation Of Transcription, Dna-Templated
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
  • Pancreas Development
  • Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
  • Positive Regulation Of Insulin Secretion
  • Positive Regulation Of Protein Export From Nucleus
  • Positive Regulation Of Protein Kinase B Signaling
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of Hormone Metabolic Process
  • Regulation Of Smooth Muscle Cell Proliferation
  • Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Response To Glucose
  • Transcription, Dna-Templated
  • Wnt Signaling Pathway, Calcium Modulating Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| TCF-4| transcription factor 7-like 2 (T-cell specific, HMG-box)| tcf4| A306_04167| AS27_02771| AS28_09774| CB1_000678036| D623_10027938| HMG-box containing TCF4| HMG box transcription factor 4| HMG box transcription factor TCF7L2| hTCF-4| I79_020783| M91_09909| M959_11510| N300_04613| N301_07045| N302_14613| N303_05182| N305_10793| N306_13968| N307_08843| N312_06765| N324_06883| N325_08860| N327_03024| N329_02451| N330_03280| N332_06180| N333_07587| N334_04570| N335_11645| N336_04660| N340_08457| N341_04776| PAL_GLEAN10014178| PANDA_001414| PsTCF4| T-cell factor 4| T-cell factor-4 variant A| T-cell factor-4 variant B| T-cell factor-4 variant C| T-cell factor-4 variant D| T-cell factor-4 variant E| T-cell factor-4 variant F| T-cell factor-4 variant G| T-cell factor-4 variant H| T-cell factor-4 variant I| T-cell factor-4 variant J| T-cell factor-4 variant K| T-cell factor-4 variant L| T-cell factor-4 variant M| T-cell factor-4 variant X2| T-cell-specific transcription factor 4| TCF4B| TCF4E| TCFL2| transcription factor 7-like 2| transcription factor 7-like 2 protein| transcription factor 7-like 2 pseudogene| transcription factor 7 like 2, T cell specific, HMG box| transcription factor 7-like 2 (T-cell specific, HMG-box) isoform A| transcription factor 7-like 2 (T-cell specific, HMG-box) isoform B| transcription factor 7-like 2 (T-cell specific, HMG-box) isoform C| transcription factor 7-like 2 (T-cell specific, HMG-box) isoform D| transcription factor 7-like 2 (T-cell specific, HMG-box) isoform E| transcription factor 7-like 2 (T-cell specific, HMG-box) isoform F| transcription factor Tcf4| TREES_T100003497| UY3_03764| XTCF-4| Y1Q_002643| Y956_01364| Z169_15483| tcf7l2

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