Summary of TCF7L2
TCF7L2 is implicated in a large variety of diseases, especially type 2 diabetes. This is mediated by impaired insulin secretion and reduced GLP-1 activation.
TCF7L2 is a transcription factor that influences the transcription of several genes. It has many functions within the cell [R].
It plays a key role in the Wnt signaling pathway. The protein is important for blood glucose homeostasis, and it is associated with increased rates of type 2 diabetes [R].
Variants in TCF7L2 may be associated with colorectal cancer [R].
The Function of TCF7L2
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
Protein names
Recommended name:
Transcription factor 7-like 2Short name:
TCF-4Alternative name(s):
HMG box transcription factor 4T-cell-specific transcription factor 4
T-cell factor 4
hTCF-4
- RS10749127 (TCF7L2) ??
- RS10885406 (TCF7L2) ??
- RS11196172 (TCF7L2) ??
- RS11196174 (TCF7L2) ??
- RS11196205 (TCF7L2) ??
- RS11196218 (TCF7L2) ??
- RS12243326 (TCF7L2) ??
- RS12255372 (TCF7L2) ??
- RS12772424 (TCF7L2) ??
- RS290475 (TCF7L2) ??
- RS290481 (TCF7L2) ??
- RS290487 (TCF7L2) ??
- RS290489 (TCF7L2) ??
- RS34872471 (TCF7L2) ??
- RS4132670 (TCF7L2) ??
- RS4506565 (TCF7L2) ??
- RS74157220 (TCF7L2) ??
- RS7895340 (TCF7L2) ??
- RS7901695 (TCF7L2) ??
- RS7903146 (TCF7L2) ??
- RS7904519 (TCF7L2) ??
- RS7917983 (TCF7L2) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
TCF7L2 Interacts with These Diseases
| Disease | Score |
Fixes
FIX: Inositol (R), GLP-1 Activators will help counteract this gene.
Substances That Increase TCF7L2
| Substances | Interaction | Organism | Category |
Substances That Decrease TCF7L2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected in epithelium from small intestine, with the highest expression at the top of the crypts and a gradient of expression from crypt to villus. Detected in colon epithelium and colon cancer, and in epithelium from mammary gland and carcinomas derived therefrom.
Gene Pathways:
Developmental stage:
Highly expressed in crypt regions and barely detectable in villi in epithelium from fetal small intestine at week 16. At week 22 expression in villi had increased strongly.
Molecular Function:
- Armadillo Repeat Domain Binding
- Beta-Catenin Binding
- Gamma-Catenin Binding
- Nuclear Hormone Receptor Binding
- Protein Kinase Binding
- Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Repressing Transcription Factor Binding
- Sequence-Specific Dna Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Factor Binding
- Transcription Regulatory Region Dna Binding
Biological Processes:
- Beta-Catenin-Tcf Complex Assembly
- Blood Vessel Development
- Canonical Wnt Signaling Pathway
- Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
- Cell Cycle Arrest
- Cell Proliferation
- Fat Cell Differentiation
- Glucose Homeostasis
- Maintenance Of Dna Repeat Elements
- Myoblast Fate Commitment
- Negative Regulation Of Canonical Wnt Signaling Pathway
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
- Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Negative Regulation Of Transcription, Dna-Templated
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
- Pancreas Development
- Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
- Positive Regulation Of Insulin Secretion
- Positive Regulation Of Protein Export From Nucleus
- Positive Regulation Of Protein Kinase B Signaling
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Hormone Metabolic Process
- Regulation Of Smooth Muscle Cell Proliferation
- Regulation Of Transcription From Rna Polymerase Ii Promoter
- Response To Glucose
- Transcription, Dna-Templated
- Wnt Signaling Pathway, Calcium Modulating Pathway