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  3. TCF3

TCF3 (Transcription factor 3)

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The Function of TCF3

Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.

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Protein names

Recommended name:

Transcription factor E2-alpha

Short name:

TCF-3

Alternative name(s):

Class B basic helix-loop-helix protein 21
bHLHb21
Immunoglobulin enhancer-binding factor E12/E47
Immunoglobulin transcription factor 1
Kappa-E2-binding factor
Transcription factor 3
Transcription factor ITF-1

TCF3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1860661 (TCF3) ??
  2. RS77866734 (TCF3) ??

Top Gene-Substance Interactions

Substances That Increase TCF3

Substances Interaction Organism Category

Substances That Decrease TCF3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • STAT3
  • STAT5A
  • IRF-1
  • ITF-2
  • AML1a
  • Lmo2
  • GATA-2
  • GATA-3
  • c-Myb

Molecular Function:

  • Beta-Catenin Binding
  • Dna Binding
  • Sequence-Specific Dna Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Transcription Regulatory Region Dna Binding
  • Bhlh Transcription Factor Binding
  • E-Box Binding
  • Enhancer Binding
  • Mitogen-Activated Protein Kinase Kinase Kinase Binding
  • Protein Heterodimerization Activity
  • Protein Homodimerization Activity
  • Repressing Transcription Factor Binding
  • Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
  • Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcription Coactivator Activity
  • Transcription Factor Binding
  • Vitamin D Response Element Binding

Biological Processes:

  • Beta-Catenin-Tcf Complex Assembly
  • Canonical Wnt Signaling Pathway
  • Chromatin Organization
  • Regulation Of Transcription, Dna-Templated
  • Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of Wnt Signaling Pathway
  • Transcription, Dna-Templated
  • B Cell Differentiation
  • B Cell Lineage Commitment
  • Immunoglobulin V(D)J Recombination
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of B Cell Proliferation
  • Positive Regulation Of Cell Cycle
  • Positive Regulation Of Muscle Cell Differentiation
  • Positive Regulation Of Neuron Differentiation
  • Positive Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of G1/S Transition Of Mitotic Cell Cycle
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A1| E12| A306_04269| AGM8| ALF2| AS27_10004| AS28_11796| bhlhb21| class A basic helix-loop-helix transcription factor G12| class B basic helix-loop-helix protein 21| D623_10015629| E12/E47| e2a| E2A2 transcription factor| E47| G12| H920_09832| helix-loop-helix protein E12| helix-loop-helix protein E47| helix-loop-helix protein HE47| I79_009247| immunoglobulin enhancer-binding factor E12/E47| immunoglobulin transcription factor 1| ITF1| KA1| kappa-E2-binding factor| M91_16673| MDA_GLEAN10011514| ME2| N300_11655| N301_00879| N302_02412| N303_04905| N307_11939| N310_08638| N322_05077| N324_05625| N332_08251| N333_05988| negative vitamin D response element-binding protein| NOL1-TCF3 fusion| PAL_GLEAN10005958| Pan1| Pan2| pancreas specific transcription factor 1c| TCF-3| TCF3B| TCF7L1| Tcfe2a| transcription factor 3b| transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)| transcription factor 3 variant 3| transcription factor 7-like 1 (T-cell specific, HMG-box)| transcription factor A1| transcription factor E2a| transcription factor E2-alpha| transcription factor E2-alpha isoform E12| transcription factor E2-alpha isoform E47| transcription factor ITF-1| transcription regulator Pan| UY3_15340| vdir| VDR interacting repressor| vitamin D receptor-interacting repressor| XE12| xtcf3| xtcf-3| Y1Q_025801| Z169_08479| tcf3

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