The Function of TCF3
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.
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Protein names
Recommended name:
Transcription factor E2-alphaShort name:
TCF-3Alternative name(s):
Class B basic helix-loop-helix protein 21bHLHb21
Immunoglobulin enhancer-binding factor E12/E47
Immunoglobulin transcription factor 1
Kappa-E2-binding factor
Transcription factor 3
Transcription factor ITF-1
- RS1860661 (TCF3) ??
- RS77866734 (TCF3) ??
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Top Gene-Substance Interactions
Substances That Increase TCF3
| Substances | Interaction | Organism | Category |
Substances That Decrease TCF3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Molecular Function:
- Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
- Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Dna Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Coactivator Activity
- Beta-Catenin Binding
- Transcription Factor Binding
- Mitogen-Activated Protein Kinase Kinase Kinase Binding
- Enhancer Binding
- Protein Homodimerization Activity
- Bhlh Transcription Factor Binding
- Sequence-Specific Dna Binding
- Transcription Regulatory Region Dna Binding
- Protein Heterodimerization Activity
- Repressing Transcription Factor Binding
- Vitamin D Response Element Binding
- E-Box Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- B Cell Lineage Commitment
- Chromatin Organization
- Transcription, Dna-Templated
- Regulation Of Transcription, Dna-Templated
- Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Wnt Signaling Pathway
- B Cell Differentiation
- Positive Regulation Of B Cell Proliferation
- Immunoglobulin V(D)J Recombination
- Positive Regulation Of Neuron Differentiation
- Positive Regulation Of Cell Cycle
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Positive Regulation Of Muscle Cell Differentiation
- Canonical Wnt Signaling Pathway
- Beta-Catenin-Tcf Complex Assembly
- Regulation Of G1/S Transition Of Mitotic Cell Cycle