The Function of TCF21
Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.
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Protein names
Recommended name:
Transcription factor 21Alternative name(s):
TCF-21Capsulin
Class A basic helix-loop-helix protein 23
bHLHa23
Epicardin
Podocyte-expressed 1
Pod-1
- RS12190287 (TCF21) ??
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Top Gene-Substance Interactions
TCF21 Interacts with These Diseases
| Disease | Score |
Substances That Increase TCF21
| Substances | Interaction | Organism | Category |
Substances That Decrease TCF21
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Molecular Function:
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Bhlh Transcription Factor Binding
- Protein Dimerization Activity
- Androgen Receptor Binding
- E-Box Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Ureteric Bud Development
- Branching Involved In Ureteric Bud Morphogenesis
- Morphogenesis Of A Branching Structure
- Kidney Development
- Vasculature Development
- Sex Determination
- Branchiomeric Skeletal Muscle Development
- Epithelial Cell Differentiation
- Glomerulus Development
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Lung Alveolus Development
- Spleen Development
- Embryonic Digestive Tract Morphogenesis
- Reproductive Structure Development
- Gland Development
- Sertoli Cell Differentiation
- Palate Development
- Lung Morphogenesis
- Lung Vasculature Development
- Bronchiole Development
- Diaphragm Development
- Respiratory System Development
- Negative Regulation Of Androgen Receptor Signaling Pathway
- Metanephric Mesenchymal Cell Differentiation
- Metanephric Glomerular Capillary Formation