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  3. TCF21

TCF21 (Transcription factor 21)

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The Function of TCF21

Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.

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Protein names

Recommended name:

Transcription factor 21

Alternative name(s):

TCF-21
Capsulin
Class A basic helix-loop-helix protein 23
bHLHa23
Epicardin
Podocyte-expressed 1
Pod-1

TCF21 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12190287 (TCF21) ??

Top Gene-Substance Interactions

TCF21 Interacts with These Diseases

Disease Score

Substances That Increase TCF21

Substances Interaction Organism Category

Substances That Decrease TCF21

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1
  • IRF-1

Molecular Function:

  • Androgen Receptor Binding
  • Bhlh Transcription Factor Binding
  • E-Box Binding
  • Protein Dimerization Activity
  • Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding

Biological Processes:

  • Branching Involved In Ureteric Bud Morphogenesis
  • Branchiomeric Skeletal Muscle Development
  • Bronchiole Development
  • Diaphragm Development
  • Embryonic Digestive Tract Morphogenesis
  • Epithelial Cell Differentiation
  • Gland Development
  • Glomerulus Development
  • Kidney Development
  • Lung Alveolus Development
  • Lung Morphogenesis
  • Lung Vasculature Development
  • Metanephric Glomerular Capillary Formation
  • Metanephric Mesenchymal Cell Differentiation
  • Morphogenesis Of A Branching Structure
  • Negative Regulation Of Androgen Receptor Signaling Pathway
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Palate Development
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Reproductive Structure Development
  • Respiratory System Development
  • Sertoli Cell Differentiation
  • Sex Determination
  • Spleen Development
  • Ureteric Bud Development
  • Vasculature Development
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| null| A306_08563| AS27_14840| AS28_03786| basic helix-loop-helix protein 21| bHLHa23| capsulin| CB1_001107008| class A basic helix-loop-helix protein 23| EGK_15332| EH28_10162| epc| epicardin| GW7_10570| H920_06311| M959_14767| Msf-1| myoRa2| N300_09727| N301_15627| N302_02879| N303_04694| N305_11909| N306_14927| N308_06456| N309_13594| N310_01557| N311_11106| N321_02802| N331_07826| N333_11880| PAL_GLEAN10014063| PANDA_011295| Pod-1| POD1| podocyte-expressed 1| putative uncharacterized protein DDB_G0267716| TCF-21| transcription factor 21-like protein| TREES_T100016802| Y1Q_009760| Y956_00345| Z169_09658| tcf21

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