The Function of TCF20
Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator.
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Protein names
Recommended name:
Transcription factor 20Short name:
TCF-20Alternative name(s):
Nuclear factor SPBPProtein AR1
Stromelysin-1 PDGF-responsive element-binding protein
SPRE-binding protein
- RS134871 (TCF20) ??
- RS134882 (TCF20) ??
- RS5758659 (TCF20) ??
- RS6002655 (TCF20) ??
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Top Gene-Substance Interactions
Substances That Increase TCF20
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Substances That Decrease TCF20
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in most tissues, except in ovary and prostate. Isoform 1 is exclusively expressed in brain, heart and testis, and this form predominates in liver and kidney. Isoform 2 predominates in lung.
Molecular Function:
- Dna Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Coactivator Activity
- Zinc Ion Binding
- Transcription Regulatory Region Dna Binding
- Poly(A) Rna Binding
Biological Processes:
- Transcription, Dna-Templated
- Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter