The Function of TCF20
Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator.
0 users want this gene increased,
0 users want it decreased
Protein names
Recommended name:
Transcription factor 20Short name:
TCF-20Alternative name(s):
Nuclear factor SPBPProtein AR1
Stromelysin-1 PDGF-responsive element-binding protein
SPRE-binding protein
- RS134871 (TCF20) ??
- RS134882 (TCF20) ??
- RS5758659 (TCF20) ??
- RS6002655 (TCF20) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
Substances That Increase TCF20
Substances | Interaction | Organism | Category |
Substances That Decrease TCF20
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
---|
Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in most tissues, except in ovary and prostate. Isoform 1 is exclusively expressed in brain, heart and testis, and this form predominates in liver and kidney. Isoform 2 predominates in lung.
Molecular Function:
- Dna Binding
- Poly(A) Rna Binding
- Transcription Coactivator Activity
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Regulatory Region Dna Binding
- Zinc Ion Binding
Biological Processes:
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Transcription, Dna-Templated
- Transcription, Dna-Templated