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  3. TCF20

TCF20 (Transcription factor 20)

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The Function of TCF20

Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator.

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Protein names

Recommended name:

Transcription factor 20

Short name:

TCF-20

Alternative name(s):

Nuclear factor SPBP
Protein AR1
Stromelysin-1 PDGF-responsive element-binding protein
SPRE-binding protein

TCF20 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS134871 (TCF20) ??
  2. RS134882 (TCF20) ??
  3. RS5758659 (TCF20) ??
  4. RS6002655 (TCF20) ??

Top Gene-Substance Interactions

Substances That Increase TCF20

Substances Interaction Organism Category

Substances That Decrease TCF20

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • ER-alpha
  • c-Myc

Tissue specificity:

Expressed in most tissues, except in ovary and prostate. Isoform 1 is exclusively expressed in brain, heart and testis, and this form predominates in liver and kidney. Isoform 2 predominates in lung.

Molecular Function:

  • Dna Binding
  • Poly(A) Rna Binding
  • Transcription Coactivator Activity
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Transcription Regulatory Region Dna Binding
  • Zinc Ion Binding

Biological Processes:

  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of Transcription, Dna-Templated
  • Transcription, Dna-Templated
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AR1| AS27_07931| AS28_12535| CB1_000168006| I79_016828| M959_13709| N300_13160| N301_05906| N302_12774| N303_02815| N305_13962| N306_07397| N307_05050| N309_04379| N310_02729| N311_12786| N312_02474| N320_05566| N321_00116| N322_13591| N324_01507| N325_12672| N327_09120| N328_07354| N330_10501| N331_04922| N333_12796| N334_13669| N335_01468| N339_05666| N340_11455| nuclear factor SPBP| PAL_GLEAN10007201| PANDA_016422| SPBP| SPRE-binding protein| stromelysin-1 PDGF-responsive element-binding protein| stromelysin-1 platelet-derived growth factor-responsive element binding protein| stromelysin PDGF responsive element binding protein transcription factor| TCF-20| transcription factor 20 (AR1)| TREES_T100012024| UY3_11064| Y1Q_022492| Y956_01273| Z169_12099| tcf20

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