The Function of TBL1XR1
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.
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Protein names
Recommended name:
F-box-like/WD repeat-containing protein TBL1XR1Alternative name(s):
Nuclear receptor corepressor/HDAC3 complex subunit TBLR1TBL1-related protein 1
Transducin beta-like 1X-related protein 1
- RS1384974 (TBL1XR1) ??
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Top Gene-Substance Interactions
Substances That Increase TBL1XR1
| Substances | Interaction | Organism | Category |
Substances That Decrease TBL1XR1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitous.
Molecular Function:
- Transcription Corepressor Activity
- Beta-Catenin Binding
- Histone Binding
- Transcription Regulatory Region Dna Binding
- Protein N-Terminus Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Response To Dietary Excess
- Transcription, Dna-Templated
- Lipid Catabolic Process
- Histone Deacetylation
- Regulation Of Camp Metabolic Process
- Multicellular Organism Growth
- Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process
- Cellular Lipid Metabolic Process
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- White Fat Cell Differentiation
- Canonical Wnt Signaling Pathway
- Fat Pad Development
- Regulation Of Triglyceride Metabolic Process