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  3. TBL1XR1

TBL1XR1 (Transducin beta like 1 X-linked receptor 1)

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The Function of TBL1XR1

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.

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Protein names

Recommended name:

F-box-like/WD repeat-containing protein TBL1XR1

Alternative name(s):

Nuclear receptor corepressor/HDAC3 complex subunit TBLR1
TBL1-related protein 1
Transducin beta-like 1X-related protein 1

TBL1XR1 SNPs

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  1. RS1384974 (TBL1XR1) ??

Top Gene-Substance Interactions

Substances That Increase TBL1XR1

Substances Interaction Organism Category

Substances That Decrease TBL1XR1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1

Tissue specificity:

Ubiquitous.

Gene Pathways:

  • Metabolism
  • Disease
  • Signal Transduction
  • Wnt signaling pathway
  • Chromatin organization

Molecular Function:

  • Beta-Catenin Binding
  • Histone Binding
  • Protein N-Terminus Binding
  • Transcription Corepressor Activity
  • Transcription Regulatory Region Dna Binding

Biological Processes:

  • Canonical Wnt Signaling Pathway
  • Cellular Lipid Metabolic Process
  • Fat Pad Development
  • Histone Deacetylation
  • Lipid Catabolic Process
  • Multicellular Organism Growth
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process
  • Regulation Of Camp Metabolic Process
  • Regulation Of Triglyceride Metabolic Process
  • Response To Dietary Excess
  • Transcription, Dna-Templated
  • White Fat Cell Differentiation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| F-box-like/WD repeat-containing protein TBL1XR1| A306_05754| AS27_14099| AS28_05363| C21| CB1_000426001| D623_10020977| dc42| F-box-like/WD repeat protein TBL1XR1| GW7_18815| H920_08801| I79_018445| IRA1| M91_18592| M959_04552| MDA_GLEAN10016667| MRD41| N300_03234| N301_07773| N302_03711| N303_10327| N305_01813| N306_05025| N307_10770| N308_11096| N309_12841| N310_03456| N311_12660| N312_03357| N320_12707| N321_12794| N322_09887| N324_10253| N325_07496| N327_12110| N329_03048| N330_10233| N332_10934| N333_03612| N334_11090| N335_10071| N336_07165| N339_03983| nuclear receptor co-repressor/HDAC3 complex subunit| nuclear receptor corepressor/HDAC3 complex subunit TBLR1| PAL_GLEAN10012880| PANDA_000230| RGD1560053| TBL1-related protein 1| tbl1xr1-a| tbl1xr1-b| TBLR1| transducin (beta)-like 1 X-linked receptor 1| transducin (beta)-like 1X-linked receptor 1| transducin beta-like 1X-related protein 1| transducin -like 1 X-linked receptor 1| UY3_04392| Y1Q_031295| Y956_04971| Z169_12877| tbl1xr1

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