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  3. TAP2

TAP2 (Transporter 2, ATP binding cassette subfamily B member)

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The Function of TAP2

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.

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Protein names

Recommended name:

SEC14-like protein 3

Alternative name(s):

Tocopherol-associated protein 2

TAP2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1015166 (TAP2) ??
  2. RS1800454 (TAP2) ??
  3. RS1894407 (TAP2) ??
  4. RS2228391 (TAP2) ??
  5. RS241428 (TAP2) ??
  6. RS241436 (TAP2) ??
  7. RS241447 (TAP2) ??
  8. RS241448 (TAP2) ??
  9. RS241453 (TAP2) ??

Top Gene-Substance Interactions

TAP2 Interacts with These Diseases

Disease Score

Substances That Increase TAP2

Substances Interaction Organism Category

Substances That Decrease TAP2

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Bare lymphocyte syndrome type 1From UniProt: Bare lymphocyte syndrome 1 (BLS1): A HLA class I deficiency. Contrary to bare lymphocyte syndromes type 2 and type 3, which are characterized by early-onset severe combined immunodeficiency, class I antigen deficiencies are not accompanied by particular pathologic manifestations during the first years of life. Systemic infections have not been described. Chronic bacterial infections, often beginning in the first decade of life, are restricted to the respiratory tract. [MIM:604571]

     From NCBI Gene: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Feb 2014] From UniProt: Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • IRF-1
  • STAT1
  • STAT1beta
  • STAT1alpha

Gene Pathways:

  • Immune System
  • Antigen processing and presentation
  • Phagosome
  • Primary immunodeficiency
  • ABC transporters

Induction:

By IFNG/IFN-gamma.

Molecular Function:

  • Lipid Binding
  • Transporter Activity
  • Atp Binding
  • Mhc Class Ib Protein Binding
  • Peptide Antigen-Transporting Atpase Activity
  • Peptide Transporter Activity
  • Tap1 Binding
  • Tapasin Binding

Biological Processes:

  • Adaptive Immune Response
  • Antigen Processing And Presentation Of Endogenous Peptide Antigen Via Mhc Class I
  • Antigen Processing And Presentation Of Endogenous Peptide Antigen Via Mhc Class Ib Via Er Pathway, Tap-Dependent
  • Antigen Processing And Presentation Of Endogenous Peptide Antigen Via Mhc Class I Via Er Pathway, Tap-Dependent
  • Antigen Processing And Presentation Of Exogenous Protein Antigen Via Mhc Class Ib, Tap-Dependent
  • Antigen Processing And Presentation Of Peptide Antigen Via Mhc Class I
  • Cytosol To Er Transport
  • Intracellular Transport Of Viral Protein In Host Cell
  • Peptide Antigen Transport
  • Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via Mhc Class I
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Antigen peptide transporter 2| ABC-transporter| ATP-binding cassette sub-family B (MDR/TAP)| ATP dependent transport protein family member| Cim| abc18| Abcb3| ABC transporter, MHC 2| Anapl_16039| antigen peptide transporter 2-like| antigen processing associated transporter 2| apt2| AS27_10948| ATP-binding cassette, sub-family B (MDR/TAP), member 3| ATP-binding cassette sub-family B member 3| CB1_000487059| D623_10004232| D6S217E| Ham2| Ham-2| histocompatibility antigen modifier 2| jas| M959_11817| major histocompatibility complex class I| MDA_GLEAN10006867| MTP2| N301_04065| PAL_GLEAN10007123| PANDA_002295| peptide supply factor 2| peptide transporter involved in antigen processing 2| peptide transporter PSF2| PSF2| PSF-2| putative transporter associated with antigen processing 2| QTAP2| really interesting new gene 11 protein| RING11| Tap-2| TAP2 protein| taransporter associated with antigen processing 2| transporter 2, ABC (ATP binding cassette)| transporter 2, ABC(ATP binding cassette)| Transporter 2 ABC (ATP binding cassette)| transporter 2 ATP-binding cassette sub-family B| transporter 2, ATP-binding cassette, sub-family B (MDR-TAP)| transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)| transporter associated with antigen presentation 2| transporter associated with antigen processing 2| TREES_T100016446| Y1| tap2

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