The Function of TANK
Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.
Protein names
Recommended name:
TRAF family member-associated NF-kappa-B activatorShort name:
I-TRAFAlternative name(s):
TRAF-interacting protein- RS7309 (TANK) ??
- RS7568498 (TANK) ??
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Top Gene-Substance Interactions
Substances That Increase TANK
| Substances | Interaction | Organism | Category |
Substances That Decrease TANK
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitous.
Molecular Function:
Biological Processes:
- Proteolysis
- Cellular Response To Dna Damage Stimulus
- Signal Transduction
- I-Kappab Kinase/Nf-Kappab Signaling
- Trif-Dependent Toll-Like Receptor Signaling Pathway
- Negative Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Cellular Response To Interleukin-1
- Cellular Response To Tumor Necrosis Factor
- Cellular Response To Ionizing Radiation
- Positive Regulation Of Protein Deubiquitination
- Positive Regulation Of Ubiquitin-Specific Protease Activity