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  3. TANK

TANK (TRAF family member associated NFKB activator)

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The Function of TANK

Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.

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Protein names

Recommended name:

TRAF family member-associated NF-kappa-B activator

Short name:

I-TRAF

Alternative name(s):

TRAF-interacting protein

TANK SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS7309 (TANK) ??
  2. RS7568498 (TANK) ??

Top Gene-Substance Interactions

Substances That Increase TANK

Substances Interaction Organism Category

Substances That Decrease TANK

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • AhR
  • NF-kappaB1
  • c-Myc
  • IRF-1
  • Sox9

Tissue specificity:

Ubiquitous.

Gene Pathways:

  • Immune System
  • RIG-I-like receptor signaling pathway
  • Innate Immune System

Molecular Function:

  • Deubiquitinase Activator Activity
  • Metal Ion Binding
  • Ubiquitin Protein Ligase Binding

Biological Processes:

  • Cellular Response To Dna Damage Stimulus
  • Cellular Response To Interleukin-1
  • Cellular Response To Ionizing Radiation
  • Cellular Response To Tumor Necrosis Factor
  • I-Kappab Kinase/Nf-Kappab Signaling
  • Negative Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
  • Positive Regulation Of Protein Deubiquitination
  • Positive Regulation Of Ubiquitin-Specific Protease Activity
  • Proteolysis
  • Signal Transduction
  • Trif-Dependent Toll-Like Receptor Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| C86182| CB1_000290021| CG15626 gene product from transcript CG15626-RB| CG15626-PA| CG15626-PB| D623_10035568| Dmel_CG15626| GW7_11988| H920_16131| I79_017129| ITRAF| I-TRAF| M91_05751| MDA_GLEAN10024204| N302_11594| N306_04110| N326_02974| N328_10123| N329_09429| N334_11915| N340_13683| N341_01742| PAL_GLEAN10025900| PANDA_013897| TANK-like protein| tank-PA| tank-PB| TRAF2| TRAF family member-associated Nf-kappa B activator| TRAF family member-associated NF-kappa-B activator| TRAF family member-associated NF-kappa-B activator-like protein| TRAF family member-associated NFKB activator| TRAF-interacting protein| TRAF interacting protein TANK| UY3_04046| Y1Q_004718| tank

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