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  3. TAC1

TAC1 (Tachykinin precursor 1)

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The Function of TAC1

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

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Protein names

Recommended name:

Protachykinin-1

Short name:

PPT

Alternative name(s):

NKA
Neuromedin L
Substance K
NPK

TAC1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10255878 (TAC1) ??
  2. RS10486003 (TAC1) ??
  3. RS1229542 (TAC1) ??

Top Gene-Substance Interactions

TAC1 Interacts with These Diseases

Disease Score

Substances That Increase TAC1

Substances Interaction Organism Category

Substances That Decrease TAC1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • GR
  • GR-alpha
  • GR-beta
  • NF-kappaB1
  • C/EBPbeta
  • c-Fos
  • GATA-1
  • NF-1

Gene Pathways:

  • Signal Transduction
  • Neuroactive ligand-receptor interaction

Molecular Function:

  • Receptor Binding

Biological Processes:

  • Antibacterial Humoral Response
  • Antifungal Humoral Response
  • Associative Learning
  • Cell-Cell Signaling
  • Cellular Response To Nerve Growth Factor Stimulus
  • Chemical Synaptic Transmission
  • Defense Response To Gram-Negative Bacterium
  • Defense Response To Gram-Positive Bacterium
  • Detection Of Abiotic Stimulus
  • Inflammatory Response
  • Innate Immune Response
  • Insemination
  • Long-Term Memory
  • Negative Regulation Of Heart Rate
  • Neuropeptide Signaling Pathway
  • Positive Regulation Of Action Potential
  • Positive Regulation Of Acute Inflammatory Response
  • Positive Regulation Of Corticosterone Secretion
  • Positive Regulation Of Cytosolic Calcium Ion Concentration
  • Positive Regulation Of Epithelial Cell Migration
  • Positive Regulation Of Lymphocyte Proliferation
  • Positive Regulation Of Ossification
  • Positive Regulation Of Renal Sodium Excretion
  • Positive Regulation Of Saliva Secretion
  • Positive Regulation Of Stress Fiber Assembly
  • Positive Regulation Of Synaptic Transmission, Cholinergic
  • Positive Regulation Of Synaptic Transmission, Gabaergic
  • Regulation Of Blood Pressure
  • Response To Hormone
  • Response To Lipopolysaccharide
  • Response To Morphine
  • Response To Pain
  • Response To Yeast
  • Sensory Perception Of Pain
  • Tachykinin Receptor Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| NK-1| NK1| PPT| A306_03470| AS28_06562| beta-PPT-A| CB1_000613001| D623_10033766| delta preprotachykinin I| gamma pptac1(preprotachykinin 1)| H920_08652| Hs.2563| I79_018000| M959_01685| N300_00989| N301_07707| N302_03099| N303_02966| N305_06366| N307_10984| N310_04875| N312_03655| N320_03866| N321_13118| N322_12360| N324_10199| N327_02247| N330_06013| N331_01231| N332_04537| N333_03378| N334_04181| N335_01050| N339_03524| N340_09309| neurokinin 1| neurokinin 2| neurokinin A| neurokinin alpha| neuromedin L| neuropeptide gamma| neuropeptide K| nk2| NKA| nkna| NPK| PANDA_008521| Ppt5fl| PPTA| PPT-A| PPTA3| preprotachykinin| preprotachykinin 1| preprotachykinin A| preprotachykinin I| protachykinin| Protachykinin-1| protachykinin-1 isoform alpha| protachykinin-1 isoform beta| protachykinin-1 preproprotein| RATPPTA3| SP| substance K| substance P| substance P, neuropeptide gamma, neurokinin A| TAC| TAC2| tachykinin| tachykinin 1| tachykinin 2| tachykinin, precursor 1| tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)| Tachykinin (substance P, neurokinin A, neuropeptide K, neuropeptide gamma)| tkn1| TREES_T100012350| UY3_08908| Y1Q_007203| Z169_07251| tac1

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