The Function of SYT11
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.
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Protein names
Recommended name:
Synaptotagmin-11Alternative name(s):
Synaptotagmin XISytXI
Top Gene-Substance Interactions
Substances That Increase SYT11
| Substances | Interaction | Organism | Category |
Substances That Decrease SYT11
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Cofactor:
Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
Molecular Function:
- Clathrin Binding
- Metal Ion Binding
- Protein Homodimerization Activity
- Syntaxin Binding
- Ubiquitin Protein Ligase Binding
Biological Processes:
- Calcium Ion-Regulated Exocytosis Of Neurotransmitter
- Calcium Ion Regulated Lysosome Exocytosis
- Negative Regulation Of Interleukin-6 Secretion
- Negative Regulation Of Membrane Invagination
- Negative Regulation Of Neurotransmitter Secretion
- Negative Regulation Of Phagocytosis
- Negative Regulation Of Synaptic Vesicle Endocytosis
- Negative Regulation Of Tumor Necrosis Factor Secretion
- Plasma Membrane Repair
- Positive Regulation Of Protein Localization To Phagocytic Vesicle
- Protein Homotetramerization
- Regulation Of Defense Response To Bacterium
- Regulation Of Phagosome Maturation
- Vesicle Fusion