The Function of SULT1A2
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.
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Protein names
Recommended name:
Sulfotransferase 1A2Short name:
ST1A2Alternative name(s):
Aryl sulfotransferase 2Phenol sulfotransferase 2
Phenol-sulfating phenol sulfotransferase 2
P-PST 2
Top Gene-Substance Interactions
SULT1A2 Interacts with These Diseases
| Disease | Score |
Substances That Increase SULT1A2
| Substances | Interaction | Organism | Category |
Substances That Decrease SULT1A2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Catecholamine Metabolic Process
- Xenobiotic Metabolic Process
- Steroid Metabolic Process
- Amine Biosynthetic Process
- Phenol-Containing Compound Metabolic Process
- 3'-Phosphoadenosine 5'-Phosphosulfate Metabolic Process
- Sulfation