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  3. SULT1A2

SULT1A2 (Sulfotransferase family 1A member 2)

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The Function of SULT1A2

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.

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Protein names

Recommended name:

Sulfotransferase 1A2

Short name:

ST1A2

Alternative name(s):

Aryl sulfotransferase 2
Phenol sulfotransferase 2
Phenol-sulfating phenol sulfotransferase 2
P-PST 2

Top Gene-Substance Interactions

SULT1A2 Interacts with These Diseases

Disease Score

Substances That Increase SULT1A2

Substances Interaction Organism Category

Substances That Decrease SULT1A2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • GR
  • GR-alpha
  • AhR
  • Sp1
  • GATA-1
  • YY1
  • Nkx5-1
  • LCR-F1

Gene Pathways:

  • Metabolism
  • Sulfur metabolism

Molecular Function:

  • Aryl Sulfotransferase Activity
  • Flavonol 3-Sulfotransferase Activity
  • Sulfotransferase Activity

Biological Processes:

  • 3'-Phosphoadenosine 5'-Phosphosulfate Metabolic Process
  • Amine Biosynthetic Process
  • Catecholamine Metabolic Process
  • Phenol-Containing Compound Metabolic Process
  • Steroid Metabolic Process
  • Sulfation
  • Xenobiotic Metabolic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

P-PST| arylamine sulfotransferase| aryl sulfotransferase 2| HAST4| phenolic-metabolizing (P) form of PST| phenol-preferring phenol sulfotransferase2| phenol-sulfating phenol sulfotransferase 2| phenol sulfotransferase 2| P-PST 2| ST1A2| STP2| sulfotransferase 1A2| sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2| thermostable phenol sulfotransferase| TSPST2| sult1a2

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