The Function of STK36
Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function (By similarity). Essential for construction of the central pair apparatus of motile cilia.
Protein names
Recommended name:
Serine/threonine-protein kinase 36Alternative name(s):
Fused homolog- RS2303565 (STK36) ??
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Top Gene-Substance Interactions
Substances That Increase STK36
| Substances | Interaction | Organism | Category |
Substances That Decrease STK36
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed at low levels in most fetal tissues, adult ovaries and at high levels in adult testis, where it is localized in germ cells.
Molecular Function:
- Atp Binding
- Magnesium Ion Binding
- Protein Serine/Threonine Kinase Activity
- Transcription Factor Binding
Biological Processes:
- Brain Development
- Cilium Assembly
- Epithelial Cilium Movement
- Positive Regulation Of Hh Target Transcription Factor Activity
- Positive Regulation Of Smoothened Signaling Pathway
- Post-Embryonic Development
- Protein Phosphorylation
- Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity