• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. STEAP4

STEAP4 (STEAP4 metalloreductase)

Loading...

The Function of STEAP4

Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Metalloreductase STEAP4

Alternative name(s):

Six-transmembrane epithelial antigen of prostate 4
SixTransMembrane protein of prostate 2
Tumor necrosis factor, alpha-induced protein 9

STEAP4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1981529 (STEAP4) ??
  2. RS8122 (STEAP4) ??

Top Gene-Substance Interactions

STEAP4 Interacts with These Diseases

Disease Score

Substances That Increase STEAP4

Substances Interaction Organism Category

Substances That Decrease STEAP4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • CUTL1
  • MRF-2
  • STAT1
  • Meis-1
  • STAT1alpha
  • E4BP4
  • Meis-1b

Tissue specificity:

Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine. Highly expressed in joints of patients with rheumatoid arthritis and localized with CD68 cells, a marker for macrophages.

Induction:

By TNF and IL1B/interleukin-1 beta in adipose tissue. Up-regulated by androgens, including testosterone and dihydrotestosterone (DHT).

Molecular Function:

  • Cupric Reductase Activity
  • Ferric-Chelate Reductase (Nadph) Activity
  • Metal Ion Binding

Biological Processes:

  • Copper Ion Import
  • Fat Cell Differentiation
  • Ferric Iron Import Into Cell
  • Iron Ion Homeostasis
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_03515| Ab1-219| AS27_03735| AS28_06607| CB1_001149001| D623_10033831| dudulin 4| H920_09002| M959_02082| metalloreductase STEAP4| N300_00946| N301_07301| N302_03054| N303_04195| N305_02182| N306_12621| N307_00823| N308_00906| N309_11142| N311_05691| N312_07169| N320_01139| N321_12082| N322_03364| N324_05578| N325_06832| N326_11679| N327_07798| N328_00403| N329_05604| N330_04158| N331_06162| N332_08815| N333_05912| N334_02658| N335_05287| N336_12580| N339_07260| N340_03132| N341_08353| PAL_GLEAN10013632| PANDA_001858| six-transmembrane epithelial antigen of prostate 4| six transmembrane epithelial antigen of the prostate 4| six transmembrane prostate protein 2| sixTransMembrane protein of prostate 2| stamp2| STEAP family member 4| tiarp| Tnfa-induced adipose-related protein| TNFAIP9| TREES_T100015490| tumor necrosis-alpha-induced adipose-related protein| tumor necrosis factor-alpha-induced adipose-related protein| tumor necrosis factor, alpha-induced protein 9| UY3_13642| Y1Q_003828| Y956_11310| Z169_07197| steap4

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved