The Function of STEAP4
Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation.
Protein names
Recommended name:
Metalloreductase STEAP4Alternative name(s):
Six-transmembrane epithelial antigen of prostate 4SixTransMembrane protein of prostate 2
Tumor necrosis factor, alpha-induced protein 9
- RS1981529 (STEAP4) ??
- RS8122 (STEAP4) ??
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Top Gene-Substance Interactions
STEAP4 Interacts with These Diseases
| Disease | Score |
Substances That Increase STEAP4
| Substances | Interaction | Organism | Category |
Substances That Decrease STEAP4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine. Highly expressed in joints of patients with rheumatoid arthritis and localized with CD68 cells, a marker for macrophages.
Induction:
By TNF and IL1B/interleukin-1 beta in adipose tissue. Up-regulated by androgens, including testosterone and dihydrotestosterone (DHT).