Disease	Score

Substances	Interaction	Organism	Category

Substances	Interaction	Organism	Category

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

The following transcription factors affect gene expression:

• NF-kappaB
• p53
• NF-kappaB1
• c-Myc

Tissue specificity:

Expressed in both pancreatic alpha- and beta-cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the developing nervous system, expressed in the cortex where it is located in the preplate at early stages and is enriched in the outer part of the germinal zone at later stages. In the cerebellum, expressed in the deep part of the external granular layer at gestational week 19. This pattern persists until birth but disappears at adulthood.

Molecular Function:

• Neuropeptide Binding
• Pdz Domain Binding
• Somatostatin Receptor Activity

Biological Processes:

• Adenylate Cyclase-Inhibiting G-Protein Coupled Receptor Signaling Pathway
• Cell-Cell Signaling
• Cellular Response To Estradiol Stimulus
• Cellular Response To Glucocorticoid Stimulus
• Cerebellum Development
• Chemical Synaptic Transmission
• Digestion
• Forebrain Development
• G-Protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
• Negative Regulation Of Cell Proliferation
• Peristalsis
• Regulation Of Muscle Contraction
• Response To Nutrient
• Response To Starvation
• Spermatogenesis

Drug Bank:

• Octreotide
• Pasireotide
• Vapreotide
• Lanreotide

*synonyms