The Function of SSTR2
Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.
Protein names
Recommended name:
Somatostatin receptor type 2Short name:
SS2RAlternative name(s):
SS-2-RSS2-R
SRIF-1
- RS1466113 (SSTR2) ??
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Top Gene-Substance Interactions
SSTR2 Interacts with These Diseases
Disease | Score |
Substances That Increase SSTR2
Substances | Interaction | Organism | Category |
Substances That Decrease SSTR2
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in both pancreatic alpha- and beta-cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the developing nervous system, expressed in the cortex where it is located in the preplate at early stages and is enriched in the outer part of the germinal zone at later stages. In the cerebellum, expressed in the deep part of the external granular layer at gestational week 19. This pattern persists until birth but disappears at adulthood.
Molecular Function:
Biological Processes:
- Adenylate Cyclase-Inhibiting G-Protein Coupled Receptor Signaling Pathway
- Cell-Cell Signaling
- Cellular Response To Estradiol Stimulus
- Cellular Response To Glucocorticoid Stimulus
- Cerebellum Development
- Chemical Synaptic Transmission
- Digestion
- Forebrain Development
- G-Protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
- Negative Regulation Of Cell Proliferation
- Peristalsis
- Regulation Of Muscle Contraction
- Response To Nutrient
- Response To Starvation
- Spermatogenesis