Disease	Score

Substances	Interaction	Organism	Category

Substances	Interaction	Organism	Category

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

The following transcription factors affect gene expression:

• NF-kappaB
• p53
• NF-kappaB1
• c-Myc

Tissue specificity:

Expressed in both pancreatic alpha- and beta-cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the developing nervous system, expressed in the cortex where it is located in the preplate at early stages and is enriched in the outer part of the germinal zone at later stages. In the cerebellum, expressed in the deep part of the external granular layer at gestational week 19. This pattern persists until birth but disappears at adulthood.

Molecular Function:

• Somatostatin Receptor Activity
• Pdz Domain Binding
• Neuropeptide Binding

Biological Processes:

• Regulation Of Muscle Contraction
• G-Protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
• Adenylate Cyclase-Inhibiting G-Protein Coupled Receptor Signaling Pathway
• Cell-Cell Signaling
• Chemical Synaptic Transmission
• Spermatogenesis
• Response To Nutrient
• Digestion
• Negative Regulation Of Cell Proliferation
• Cerebellum Development
• Peristalsis
• Forebrain Development
• Response To Starvation
• Cellular Response To Glucocorticoid Stimulus
• Cellular Response To Estradiol Stimulus

Drug Bank:

• Octreotide
• Pasireotide
• Vapreotide
• Lanreotide

*synonyms