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  3. SSTR2

SSTR2 (Somatostatin receptor 2)

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The Function of SSTR2

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

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Protein names

Recommended name:

Somatostatin receptor type 2

Short name:

SS2R

Alternative name(s):

SS-2-R
SS2-R
SRIF-1

SSTR2 SNPs

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  1. RS1466113 (SSTR2) ??

Top Gene-Substance Interactions

SSTR2 Interacts with These Diseases

Disease Score

Substances That Increase SSTR2

Substances Interaction Organism Category

Substances That Decrease SSTR2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • p53
  • NF-kappaB1
  • c-Myc

Tissue specificity:

Expressed in both pancreatic alpha- and beta-cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the developing nervous system, expressed in the cortex where it is located in the preplate at early stages and is enriched in the outer part of the germinal zone at later stages. In the cerebellum, expressed in the deep part of the external granular layer at gestational week 19. This pattern persists until birth but disappears at adulthood.

Gene Pathways:

  • Signal Transduction
  • Neuroactive ligand-receptor interaction
  • Gastric acid secretion

Molecular Function:

  • Neuropeptide Binding
  • Pdz Domain Binding
  • Somatostatin Receptor Activity

Biological Processes:

  • Adenylate Cyclase-Inhibiting G-Protein Coupled Receptor Signaling Pathway
  • Cell-Cell Signaling
  • Cellular Response To Estradiol Stimulus
  • Cellular Response To Glucocorticoid Stimulus
  • Cerebellum Development
  • Chemical Synaptic Transmission
  • Digestion
  • Forebrain Development
  • G-Protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
  • Negative Regulation Of Cell Proliferation
  • Peristalsis
  • Regulation Of Muscle Contraction
  • Response To Nutrient
  • Response To Starvation
  • Spermatogenesis

Drug Bank:

  • Octreotide
  • Pasireotide
  • Vapreotide
  • Lanreotide
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_16454| AS27_15194| AS28_04230| CB1_000245019| EGK_08930| GW7_09376| H920_12301| M959_10666| MDA_GLEAN10015893| N300_05042| N301_13654| N302_09313| N303_08574| N305_07952| N306_04672| N307_13005| N309_09578| N310_08817| N311_06100| N312_00259| N320_04723| N321_09462| N322_06669| N324_03000| N325_06515| N326_04902| N327_10345| N328_09275| N329_05447| N330_10042| N332_08616| N333_04948| N335_12100| N336_01489| N339_08981| N340_08113| N341_09509| PAL_GLEAN10014797| PANDA_015850| Smstr2| Smstr-2| somatostatin receptor subtype 2| Somatostatin receptor type 2| somatostatin receptor type 2-like protein| somatostatin type 2 receptor| somatotropin release-inhibiting factor receptor| SRIF-1| SS2R| SS-2-R| SS2-R| sst2| SSTR-2| TREES_T100007274| UY3_03489| Y1Q_026032| Y956_08453| sstr2

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