The Function of SRSF10
Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250).
Protein names
Recommended name:
Serine/arginine-rich splicing factor 10Short name:
TASRAlternative name(s):
40 kDa SR-repressor proteinSRrp40
FUS-interacting serine-arginine-rich protein 1
Splicing factor SRp38
Splicing factor, arginine/serine-rich 13A
TLS-associated protein with Ser-Arg repeats
TLS-associated protein with SR repeats
TLS-associated serine-arginine protein
TLS-associated SR protein
- RS6667686 (SRSF10) ??
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Top Gene-Substance Interactions
SRSF10 Interacts with These Diseases
| Disease | Score |
Substances That Increase SRSF10
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Substances That Decrease SRSF10
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Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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