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  3. SRSF10

SRSF10 (Serine and arginine rich splicing factor 10)

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The Function of SRSF10

Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250).

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Protein names

Recommended name:

Serine/arginine-rich splicing factor 10

Short name:

TASR

Alternative name(s):

40 kDa SR-repressor protein
SRrp40
FUS-interacting serine-arginine-rich protein 1
Splicing factor SRp38
Splicing factor, arginine/serine-rich 13A
TLS-associated protein with Ser-Arg repeats
TLS-associated protein with SR repeats
TLS-associated serine-arginine protein
TLS-associated SR protein

SRSF10 SNPs

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  1. RS6667686 (SRSF10) ??

Top Gene-Substance Interactions

SRSF10 Interacts with These Diseases

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Substances That Increase SRSF10

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Substances That Decrease SRSF10

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

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