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  3. SRR

SRR (Serine racemase)

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The Function of SRR

Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.

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Protein names

Recommended name:

Serine racemase

Alternative name(s):

D-serine ammonia-lyase
D-serine dehydratase
L-serine ammonia-lyase
L-serine dehydratase

SRR SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS391300 (SRR) ??
  2. RS4523957 (SRR) ??

Top Gene-Substance Interactions

SRR Interacts with These Diseases

Disease Score

Substances That Increase SRR

Substances Interaction Organism Category

Substances That Decrease SRR

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CUTL1
  • CREB
  • deltaCREB
  • GATA-1
  • E2F-1
  • Lmo2
  • YY1
  • Bach2
  • c-Myb

Tissue specificity:

Brain: expressed at high levels in hippocampus and corpus callosum, intermediate levels in substantia nigra and caudate, and low levels in amygdala, thalamus, and subthalamic nuclei. Expressed in heart, skeletal muscle, kidney and liver.

Gene Pathways:

  • Glycine, serine and threonine metabolism

Enzyme Regulation:

Allosterically activated by magnesium, and possibly also other divalent metal cations. Allosterically activated by ATP, ADP or GTP. Competitively inhibited by malonate.

Molecular Function:

  • Atp Binding
  • Calcium Ion Binding
  • D-Serine Ammonia-Lyase Activity
  • Glycine Binding
  • L-Serine Ammonia-Lyase Activity
  • Magnesium Ion Binding
  • Pdz Domain Binding
  • Protein Homodimerization Activity
  • Pyridoxal Phosphate Binding
  • Serine Racemase Activity
  • Threonine Racemase Activity

Biological Processes:

  • Aging
  • Brain Development
  • D-Serine Biosynthetic Process
  • D-Serine Metabolic Process
  • L-Serine Metabolic Process
  • Protein Homotetramerization
  • Pyruvate Biosynthetic Process
  • Response To Lipopolysaccharide
  • Response To Morphine
  • Serine Family Amino Acid Metabolic Process

Drug Bank:

  • L-Serine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| pre-rRNA-processing protein TSR1 homolog| SGSM2| small G protein signaling modulator 2| RUN and TBC1 domain containing 1| A306_15745| AS27_13412| D-serine ammonia-lyase| D-serine dehydratase| EGK_07999| GW7_05081| H920_13016| ILV1| ISO1| L-serine ammonia-lyase| L-serine dehydratase| M100034| M91_10031| M959_13422| N300_03481| N301_12370| N302_16375| N303_12137| N305_15088| N306_10480| N307_07380| N308_00558| N309_11636| N310_10530| N320_01417| N321_06816| N322_07053| N324_12528| N325_10492| N326_08772| N327_04099| N329_09946| N330_06321| N332_11983| N333_04746| N334_08712| N335_08426| N341_08306| PAL_GLEAN10020019| PANDA_006462| Phenylserine dehydratase| Rgsc34| RUTBC1| serine racemase-like protein| Srs| TREES_T100019015| TSR1| UY3_05103| Z169_00650| srr

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