The Function of SRR
Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
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Protein names
Recommended name:
Serine racemaseAlternative name(s):
D-serine ammonia-lyaseD-serine dehydratase
L-serine ammonia-lyase
L-serine dehydratase
- RS391300 (SRR) ??
- RS4523957 (SRR) ??
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Top Gene-Substance Interactions
SRR Interacts with These Diseases
| Disease | Score |
Substances That Increase SRR
| Substances | Interaction | Organism | Category |
Substances That Decrease SRR
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Brain: expressed at high levels in hippocampus and corpus callosum, intermediate levels in substantia nigra and caudate, and low levels in amygdala, thalamus, and subthalamic nuclei. Expressed in heart, skeletal muscle, kidney and liver.
Gene Pathways:
Enzyme Regulation:
Allosterically activated by magnesium, and possibly also other divalent metal cations. Allosterically activated by ATP, ADP or GTP. Competitively inhibited by malonate.
Molecular Function:
- Atp Binding
- Calcium Ion Binding
- D-Serine Ammonia-Lyase Activity
- Glycine Binding
- L-Serine Ammonia-Lyase Activity
- Magnesium Ion Binding
- Pdz Domain Binding
- Protein Homodimerization Activity
- Pyridoxal Phosphate Binding
- Serine Racemase Activity
- Threonine Racemase Activity
Biological Processes:
- Aging
- Brain Development
- D-Serine Biosynthetic Process
- D-Serine Metabolic Process
- L-Serine Metabolic Process
- Protein Homotetramerization
- Pyruvate Biosynthetic Process
- Response To Lipopolysaccharide
- Response To Morphine
- Serine Family Amino Acid Metabolic Process