The Function of SRR
Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
0 users want this gene increased,
0 users want it decreased
Protein names
Recommended name:
Serine racemaseAlternative name(s):
D-serine ammonia-lyaseD-serine dehydratase
L-serine ammonia-lyase
L-serine dehydratase
- RS391300 (SRR) ??
- RS4523957 (SRR) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
SRR Interacts with These Diseases
| Disease | Score |
Substances That Increase SRR
| Substances | Interaction | Organism | Category |
Substances That Decrease SRR
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Brain: expressed at high levels in hippocampus and corpus callosum, intermediate levels in substantia nigra and caudate, and low levels in amygdala, thalamus, and subthalamic nuclei. Expressed in heart, skeletal muscle, kidney and liver.
Gene Pathways:
Enzyme Regulation:
Allosterically activated by magnesium, and possibly also other divalent metal cations. Allosterically activated by ATP, ADP or GTP. Competitively inhibited by malonate.
Molecular Function:
- Magnesium Ion Binding
- L-Serine Ammonia-Lyase Activity
- Calcium Ion Binding
- Atp Binding
- Glycine Binding
- Threonine Racemase Activity
- Pdz Domain Binding
- Pyridoxal Phosphate Binding
- Serine Racemase Activity
- Protein Homodimerization Activity
- D-Serine Ammonia-Lyase Activity
Biological Processes:
- L-Serine Metabolic Process
- Brain Development
- Aging
- Serine Family Amino Acid Metabolic Process
- Response To Lipopolysaccharide
- Pyruvate Biosynthetic Process
- Response To Morphine
- Protein Homotetramerization
- D-Serine Metabolic Process
- D-Serine Biosynthetic Process