The Function of SRGN
Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.
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Protein names
Recommended name:
SerglycinShort name:
P.PGAlternative name(s):
Hematopoietic proteoglycan core proteinPlatelet proteoglycan core protein
Secretory granule proteoglycan core protein
Top Gene-Substance Interactions
Substances That Increase SRGN
| Substances | Interaction | Organism | Category |
Substances That Decrease SRGN
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
By Epstein-Barr virus (EBV).
Biological Processes:
- Platelet Degranulation
- Granzyme-Mediated Apoptotic Signaling Pathway
- Protein Processing
- Negative Regulation Of Bone Mineralization
- Biomineral Tissue Development
- Mast Cell Secretory Granule Organization
- T Cell Secretory Granule Organization
- Maintenance Of Protease Location In Mast Cell Secretory Granule
- Maintenance Of Granzyme B Location In T Cell Secretory Granule
- Negative Regulation Of Cytokine Secretion
- Protease Localization To Mast Cell Secretory Granule