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  3. SRGN

SRGN (Serglycin)

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The Function of SRGN

Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.

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Protein names

Recommended name:

Serglycin

Short name:

P.PG

Alternative name(s):

Hematopoietic proteoglycan core protein
Platelet proteoglycan core protein
Secretory granule proteoglycan core protein

Top Gene-Substance Interactions

Substances That Increase SRGN

Substances Interaction Organism Category

Substances That Decrease SRGN

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • STAT1
  • TBP
  • STAT1alpha
  • Lmo2
  • TFIID

Gene Pathways:

  • Hemostasis

Induction:

By Epstein-Barr virus (EBV).

Biological Processes:

  • Biomineral Tissue Development
  • Granzyme-Mediated Apoptotic Signaling Pathway
  • Maintenance Of Granzyme B Location In T Cell Secretory Granule
  • Maintenance Of Protease Location In Mast Cell Secretory Granule
  • Mast Cell Secretory Granule Organization
  • Negative Regulation Of Bone Mineralization
  • Negative Regulation Of Cytokine Secretion
  • Platelet Degranulation
  • Protease Localization To Mast Cell Secretory Granule
  • Protein Processing
  • T Cell Secretory Granule Organization
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| chondroitin sulfate proteoglycan core protein| PRG1| A306_12638| AS27_09459| AS28_09605| CB1_000533041| cytolytic granule proteoglycan core protein| fk86b08| gp600| GW7_10629| H920_01588| hematopoetic proteoglycan core peptide| hematopoetic proteoglycan core protein| hematopoietic proteoglycan core protein| M91_19592| M959_01264| mastocytoma proteoglycan core protein| MDA_GLEAN10020825| N300_07703| N301_13551| N302_07335| N305_07031| N306_03465| N307_01272| N308_03723| N309_15549| N310_10016| N311_06855| N312_00238| N320_02475| N321_06352| N324_03800| N325_06417| N326_08997| N327_04901| N328_12484| N329_01084| N331_07514| N332_01944| N333_11859| N334_08396| N335_04662| N336_06288| N340_04551| PAL_GLEAN10020551| PANDA_001612| PG19 core protein| Pgsg| platelet proteoglycan core protein| p.PG| PPG| PRG| proteoglycan 10K core protein| proteoglycan 1 precursor-like| proteoglycan 1, secretory granule| proteoglycan peptide core protein| proteoglycan protein core for mast cell secretory granule| proteoglycan, secretory granule| secretory granule proteoglycan core peptide| secretory granule proteoglycan core protein| serglycin-like protein| serglycin proteoglycan| Sgc| TREES_T100015942| Y1Q_006978| Y956_12770| Z169_04126| srgn

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