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  3. SREBF1

SREBF1 (Sterol regulatory element binding transcription factor 1)

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The Function of SREBF1

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').

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Protein names

Recommended name:

Sterol regulatory element-binding protein 1

Alternative name(s):

SREBP-1
Class D basic helix-loop-helix protein 1
bHLHd1
Sterol regulatory element-binding transcription factor 1

SREBF1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11868035 (SREBF1) ??
  2. RS1889018 (SREBF1) ??

Top Gene-Substance Interactions

SREBF1 Interacts with These Diseases

Disease Score

Substances That Increase SREBF1

Substances Interaction Organism Category

Substances That Decrease SREBF1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • NF-kappaB1
  • PPAR-alpha
  • C/EBPalpha
  • Sp1
  • SREBP-1a
  • SREBP-1c
  • SREBP-1b

Tissue specificity:

Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle.

Gene Pathways:

  • Metabolism
  • Circadian Clock
  • Mus musculus biological processes
  • Insulin signaling pathway

Molecular Function:

  • Chromatin Binding
  • Dna Binding
  • Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
  • Sterol Response Element Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding

Biological Processes:

  • Aging
  • Cellular Response To Fatty Acid
  • Cellular Response To Starvation
  • Cholesterol Metabolic Process
  • Circadian Rhythm
  • Fat Cell Differentiation
  • Insulin Receptor Signaling Pathway
  • Lipid Biosynthetic Process
  • Lipid Metabolic Process
  • Lung Development
  • Mrna Transcription From Rna Polymerase Ii Promoter
  • Negative Regulation Of Insulin Secretion
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Cholesterol Biosynthetic Process
  • Positive Regulation Of Histone Deacetylation
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Triglyceride Biosynthetic Process
  • Regulation Of Fatty Acid Metabolic Process
  • Regulation Of Heart Rate By Chemical Signal
  • Regulation Of Mitophagy
  • Regulation Of Protein Stability
  • Regulation Of Protein Targeting To Mitochondrion
  • Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Response To Camp
  • Response To Food
  • Response To Glucagon
  • Response To Glucose
  • Response To Progesterone
  • Response To Retinoic Acid
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ADD1| ADD-1| adipocyte determination and differentiation-dependent factor 1| adipocyte determination- and differentiation-dependent factor 1| bHLHd1| CB1_000221026| class D basic helix-loop-helix protein 1| D623_10023215| H920_10920| I79_010155| N300_09029| N303_00799| PAL_GLEAN10008635| SCREBP1| SREBF2| Srebp1| SREBP-1| SREBP1a| SREBP-1a| SREBP1c| SREBP-1C| sterol regulatory binding transcription factor 1| sterol regulatory element binding protein 1| sterol regulatory element binding protein-1| sterol regulatory element binding-protein 1| Sterol regulatory element-binding protein 1| sterol regulatory element-binding protein 1-like| sterol regulatory element-binding protein 1-like protein| Sterol regulatory element-binding protein 2| Sterol regulatory element-binding transcription factor 1| sterol regulatory element binding transcription factor 2| sterol response element binding protein 1| TREES_T100005662| UY3_09805| Y1Q_002990| Y956_00629| srebf1

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