The Function of SREBF1
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').
Protein names
Recommended name:
Sterol regulatory element-binding protein 1Alternative name(s):
SREBP-1Class D basic helix-loop-helix protein 1
bHLHd1
Sterol regulatory element-binding transcription factor 1
- RS11868035 (SREBF1) ??
- RS1889018 (SREBF1) ??
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Top Gene-Substance Interactions
SREBF1 Interacts with These Diseases
| Disease | Score |
Substances That Increase SREBF1
| Substances | Interaction | Organism | Category |
Substances That Decrease SREBF1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle.
Gene Pathways:
Molecular Function:
- Chromatin Binding
- Dna Binding
- Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
- Sterol Response Element Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
Biological Processes:
- Aging
- Cellular Response To Fatty Acid
- Cellular Response To Starvation
- Cholesterol Metabolic Process
- Circadian Rhythm
- Fat Cell Differentiation
- Insulin Receptor Signaling Pathway
- Lipid Biosynthetic Process
- Lipid Metabolic Process
- Lung Development
- Mrna Transcription From Rna Polymerase Ii Promoter
- Negative Regulation Of Insulin Secretion
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Cholesterol Biosynthetic Process
- Positive Regulation Of Histone Deacetylation
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Triglyceride Biosynthetic Process
- Regulation Of Fatty Acid Metabolic Process
- Regulation Of Heart Rate By Chemical Signal
- Regulation Of Mitophagy
- Regulation Of Protein Stability
- Regulation Of Protein Targeting To Mitochondrion
- Regulation Of Transcription From Rna Polymerase Ii Promoter
- Response To Camp
- Response To Food
- Response To Glucagon
- Response To Glucose
- Response To Progesterone
- Response To Retinoic Acid