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  3. SRD5A2

SRD5A2 (Steroid 5 alpha-reductase 2)

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Summary of SRD5A2

The SRD5A2 gene encodes an enzyme called steroid 5-alpha reductase 2. It processes androgens, which are hormones that direct male sexual development. It helps directs the development of the external genitalia and male secondary sex characteristics (R). 

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The Function of SRD5A2

Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

Protein names

Recommended name:

3-oxo-5-alpha-steroid 4-dehydrogenase 2

Short name:

S5AR 2

Alternative name(s):

5 alpha-SR2
SR type 2
Steroid 5-alpha-reductase 2
Type II 5-alpha reductase

SRD5A2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12470143 (SRD5A2) ??
  2. RS2208532 (SRD5A2) ??
  3. RS523349 (SRD5A2) ??
  4. RS559555 (SRD5A2) ??
  5. RS632148 (SRD5A2) ??
  6. RS9282858 (SRD5A2) ??
  7. RS9332964 (SRD5A2) ??
  8. RS9332975 (SRD5A2) ??

Top Gene-Substance Interactions

SRD5A2 Interacts with These Diseases

Disease Score

Substances That Increase SRD5A2

Substances Interaction Organism Category

Substances That Decrease SRD5A2

Substances Interaction Organism Category

Advanced Summary

     5-alpha reductase deficiency About 50 mutations in the SRD5A2 gene have been identified in people with 5-alpha reductase deficiency. Most of these mutations change single protein building blocks (amino acids) in steroid 5-alpha reductase 2. Some of these genetic changes render the enzyme completely inactive. Other mutations reduce but do not eliminate the enzyme's function. As a result of SRD5A2 mutations, the body cannot effectively convert testosterone to DHT in reproductive tissues. A shortage of DHT disrupts the formation of external genitalia before birth. People with 5-alpha reductase deficiency are genetically male, with one X and one Y chromosome in each cell, but they may be born with external genitalia that look predominantly female, or that are not clearly male or clearly female (sometimes called ambiguous genitalia). Other affected infants have external genitalia that appear predominantly male, but they often have an unusually small penis (micropenis) and the urethra opening on the underside of the penis (hypospadias). During puberty, the testes produce more testosterone. Researchers believe that people with 5-alpha reductase deficiency develop secondary male sex characteristics in response to higher levels of this hormone. Some affected people also retain a small amount of 5-alpha reductase 2 activity, which may produce DHT and contribute to the development of secondary sex characteristics during puberty. prostate cancer Genetics Home Reference provides information about prostate cancer. cancers Certain normal variations (polymorphisms) in the SRD5A2 gene may be associated with prostate cancer. Two of these polymorphisms have been studied extensively. The most common variation replaces the amino acid valine with the amino acid leucine at position 89 in steroid 5-alpha reductase 2 (written as Val89Leu or V89L). The other variation replaces the amino acid alanine with the amino acid threonine at position 49 in the enzyme (written as Ala49Thr or A49T). Some studies have suggested that these variations are associated with an increased risk of developing prostate cancer or having a more aggressive form of the disease. Other studies, however, have not shown these associations. It remains unclear what role SRD5A2 polymorphisms play in prostate cancer risk. Some gene mutations are acquired during a person's lifetime and are present only in certain cells. These changes, which are called somatic mutations, are not inherited. Studies have shown that somatic SRD5A2 mutations in prostate cancer cells may be associated with the progression of prostate cancer. These mutations may increase the activity of steroid 5-alpha reductase 2, which would raise the levels of DHT in prostate tissue. Research has shown that androgens such as DHT can stimulate prostate cancer growth. other disorders In women, certain polymorphisms in the SRD5A2 gene may affect the risk of developing a condition called polycystic ovary syndrome (PCOS). PCOS is characterized by a hormonal imbalance that can lead to irregular menstruation, acne, excess body hair (hirsutism), and weight gain. Some genetic variations increase the activity of steroid 5-alpha reductase 2 in the ovaries, which could contribute to the signs and symptoms of this condition. Other variations, including the common polymorphism Val89Leu, reduce the activity of steroid 5-alpha reductase 2 and are associated with a reduced risk of developing PCOS.

     The SRD5A2 gene provides instructions for making an enzyme called steroid 5-alpha reductase 2. This enzyme is involved in processing androgens, which are hormones that direct male sexual development. Specifically, the enzyme is responsible for a chemical reaction that converts the hormone testosterone to a more potent androgen, dihydrotestosterone (DHT), in male reproductive tissues. Testosterone and DHT are essential for the normal development of male sex characteristics. Before birth, testosterone is responsible for the formation of internal male genitalia, including the tubes that collect sperm and carry it out of the testes (the epididymis and vas deferens) and glands that help produce semen (the seminal vesicles). DHT directs the development of the external genitalia, including the penis and scrotum, and the prostate gland. During puberty, these two hormones also play an important role in the development of male secondary sex characteristics such as the growth of facial and body hair, increased muscle mass, and deepening of the voice.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2

Tissue specificity:

Expressed in high levels in the prostate and many other androgen-sensitive tissues.

Gene Pathways:

  • Metabolism
  • Steroid hormone biosynthesis
  • Steroid hormones
  • Prostate cancer

Molecular Function:

  • 3-Oxo-5-Alpha-Steroid 4-Dehydrogenase Activity
  • Amide Binding
  • Cholestenone 5-Alpha-Reductase Activity
  • Sterol 5-Alpha Reductase Activity

Biological Processes:

  • Androgen Biosynthetic Process
  • Androgen Metabolic Process
  • Biphenyl Metabolic Process
  • Bone Development
  • Cell-Cell Signaling
  • Cell Differentiation
  • Dibenzo-P-Dioxin Metabolic Process
  • Female Genitalia Development
  • Hippocampus Development
  • Hypothalamus Development
  • Male Genitalia Development
  • Male Gonad Development
  • Phthalate Metabolic Process
  • Response To Follicle-Stimulating Hormone
  • Response To Nutrient Levels
  • Response To Peptide Hormone
  • Response To Steroid Hormone
  • Response To Testosterone
  • Steroid Biosynthetic Process
  • Steroid Catabolic Process

Drug Bank:

  • Azelaic Acid
  • Dutasteride
  • Finasteride
  • Spironolactone
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 3-oxo-5-alpha-steroid 4-dehydrogenase 2| 5 alpha-SR2| 5ART2| A306_05730| AS27_08663| AS28_05126| CB1_000655012| D623_10019017| GW7_02629| M959_06649| N300_06960| N301_13679| N302_08506| N303_10251| N305_12553| N306_08946| N307_07470| N308_06104| N309_04605| N310_06390| N311_05082| N312_10837| N320_03405| N321_08859| N324_10318| N325_05086| N326_05432| N327_13831| N328_05632| N329_10889| N330_10406| N331_09764| N333_01267| N334_13729| N339_10599| N340_14919| N341_08613| PAL_GLEAN10020308| PANDA_016767| prostatic steroid 5-alpha-reductase type II| S5AR 2| SRD5alpha2| SR type 2| ST5AR2| Steroid 5-alpha-reductase 2| steroid 5-alpha-reductase 2-like protein| steroid-5-alpha-reductase alpha polypeptide 2| steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)| steroid 5 alpha reductase type2| steroid 5 alpha-reductase type 2 isoenzyme| TREES_T100019987| type II 5-alpha reductase| Y956_12632| Z169_01536| srd5a2

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