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  3. SRD5A1

SRD5A1 (Steroid 5 alpha-reductase 1)

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The Function of SRD5A1

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

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Protein names

Recommended name:

3-oxo-5-alpha-steroid 4-dehydrogenase 1

Short name:

S5AR 1

Alternative name(s):

SR type 1
Steroid 5-alpha-reductase 1

SRD5A1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS166050 (SRD5A1) ??
  2. RS472402 (SRD5A1) ??

Top Gene-Substance Interactions

SRD5A1 Interacts with These Diseases

Disease Score

Substances That Increase SRD5A1

Substances Interaction Organism Category

Substances That Decrease SRD5A1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AhR
  • PPAR-alpha
  • HNF-4alpha1
  • HNF-4alpha2
  • Sp1

Tissue specificity:

Liver and prostate (at a low level).

Gene Pathways:

  • Metabolism
  • Steroid hormone biosynthesis
  • Steroid hormones

Induction:

Its expression is regulated by androgens such as testosterone.

Molecular Function:

  • 3-Oxo-5-Alpha-Steroid 4-Dehydrogenase Activity
  • Amide Binding
  • Cholestenone 5-Alpha-Reductase Activity
  • Electron Carrier Activity
  • Nadph Binding

Biological Processes:

  • Androgen Biosynthetic Process
  • Bone Development
  • Cell Differentiation
  • Cellular Response To Camp
  • Cellular Response To Dexamethasone Stimulus
  • Cellular Response To Epinephrine Stimulus
  • Cellular Response To Estradiol Stimulus
  • Cellular Response To Growth Factor Stimulus
  • Cellular Response To Insulin Stimulus
  • Cellular Response To Starvation
  • Cellular Response To Testosterone Stimulus
  • Cerebral Cortex Development
  • Circadian Sleep/Wake Cycle, Rem Sleep
  • Diterpenoid Metabolic Process
  • Female Genitalia Development
  • Hippocampus Development
  • Hypothalamus Development
  • Liver Development
  • Male Genitalia Development
  • Male Gonad Development
  • Pituitary Gland Development
  • Progesterone Metabolic Process
  • Response To Estrogen
  • Response To Follicle-Stimulating Hormone
  • Response To Fungicide
  • Response To Growth Hormone
  • Response To Muscle Activity
  • Serotonin Metabolic Process
  • Sex Determination
  • Spinal Cord Development
  • Steroid Biosynthetic Process
  • Thalamus Development
  • Urogenital System Development

Drug Bank:

  • Finasteride
  • Levonorgestrel
  • Oxymetholone
  • Spironolactone
  • Dutasteride
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 3-oxo-5-alpha-steroid 4-dehydrogenase 1| 3-oxo-5-alpha-steroid 4-dehydrogenase 1-like| 3-oxo-5-alpha-steroid 4-dehydrogenase 1-like protein| AS27_04670| AS28_02660| CB1_064113005| M91_05142| M959_13371| MDA_GLEAN10025876| N300_02795| N301_00396| N302_06189| N303_00073| N305_08204| N306_10569| N307_13974| N308_00140| N310_10582| N311_04253| N321_05107| N322_00763| N324_06642| N325_02766| N327_06304| N328_02657| N329_06197| N330_11671| N332_12000| N333_02437| N335_09810| N339_02044| N340_13773| N341_02852| PAL_GLEAN10006284| PANDA_012596| prostatic steroid 5-alpha-reductase type I| S5AR 1| Srd5a-1| SRD5alpha1| SR type 1| Steroid 5-alpha-reductase 1| steroid-5-alpha-reductase alpha polypeptide 1| steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-st| steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)| steroid 5 alpha-reductase type 1 isoenzyme| steroid 5-alpha-reductase type I| TREES_T100020281| type 1 5alpha-reductase| Y1Q_019940| Y956_16499| Z169_05915| srd5a1

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