The Function of SRD5A1
Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
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Protein names
Recommended name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1Short name:
S5AR 1Alternative name(s):
SR type 1Steroid 5-alpha-reductase 1
- RS166050 (SRD5A1) ??
- RS472402 (SRD5A1) ??
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Top Gene-Substance Interactions
SRD5A1 Interacts with These Diseases
| Disease | Score |
Substances That Increase SRD5A1
| Substances | Interaction | Organism | Category |
Substances That Decrease SRD5A1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Liver and prostate (at a low level).
Gene Pathways:
Induction:
Its expression is regulated by androgens such as testosterone.
Molecular Function:
- 3-Oxo-5-Alpha-Steroid 4-Dehydrogenase Activity
- Electron Carrier Activity
- Amide Binding
- Cholestenone 5-Alpha-Reductase Activity
- Nadph Binding
Biological Processes:
- Urogenital System Development
- Liver Development
- Steroid Biosynthetic Process
- Androgen Biosynthetic Process
- Sex Determination
- Male Gonad Development
- Cellular Response To Starvation
- Response To Muscle Activity
- Diterpenoid Metabolic Process
- Spinal Cord Development
- Hippocampus Development
- Thalamus Development
- Hypothalamus Development
- Pituitary Gland Development
- Cerebral Cortex Development
- Cell Differentiation
- Male Genitalia Development
- Female Genitalia Development
- Response To Follicle-Stimulating Hormone
- Cellular Response To Insulin Stimulus
- Serotonin Metabolic Process
- Progesterone Metabolic Process
- Circadian Sleep/Wake Cycle, Rem Sleep
- Response To Estrogen
- Bone Development
- Response To Growth Hormone
- Response To Fungicide
- Cellular Response To Camp
- Cellular Response To Growth Factor Stimulus
- Cellular Response To Estradiol Stimulus
- Cellular Response To Testosterone Stimulus
- Cellular Response To Dexamethasone Stimulus
- Cellular Response To Epinephrine Stimulus