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  3. SPTBN2

SPTBN2 (Spectrin beta, non-erythrocytic 2)

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The Function of SPTBN2

Probably plays an important role in neuronal membrane skeleton.

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Protein names

Recommended name:

Spectrin beta chain, non-erythrocytic 2

Alternative name(s):

Beta-III spectrin
Spinocerebellar ataxia 5 protein

Top Gene-Substance Interactions

Substances That Increase SPTBN2

Substances Interaction Organism Category

Substances That Decrease SPTBN2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • TBP
  • TFIID

Tissue specificity:

Highly expressed in brain, kidney, pancreas, and liver, and at lower levels in lung and placenta.

Gene Pathways:

  • Immune System

Molecular Function:

  • Actin Binding
  • Cadherin Binding Involved In Cell-Cell Adhesion
  • Phospholipid Binding
  • Ras Guanyl-Nucleotide Exchange Factor Activity
  • Structural Constituent Of Cytoskeleton

Biological Processes:

  • Actin Filament Capping
  • Adult Behavior
  • Antigen Processing And Presentation Of Exogenous Peptide Antigen Via Mhc Class Ii
  • Axon Guidance
  • Cerebellar Purkinje Cell Layer Morphogenesis
  • Er To Golgi Vesicle-Mediated Transport
  • Mapk Cascade
  • Multicellular Organism Growth
  • Synapse Assembly
  • Vesicle-Mediated Transport
  • Cellular Response To Ethanol
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| beta-III spectrin| beta-spectrin 3| beta SpIII sigma 1| CB1_000429014| D623_10030787| fb48h06| glutamate transporter EAAT4-associated protein 41| GTRAP41| H920_10218| I79_018394| M91_14015| MDA_GLEAN10017847| PAL_GLEAN10011316| SCA5| SCAR14| spectrin beta 3| spectrin beta chain, brain 2| Spectrin beta chain, brain 2 isoform 1-like protein| spectrin beta chain, non-erythrocytic 2| spectrin beta III sigma 2| spectrin, beta, non-erythrocytic 2| spectrin-like protein GTRAP41| spectrin, non-erythroid beta chain 2| spinocerebellar ataxia 5 protein| Spnb3| TREES_T100012736| sptbn2

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