The Function of SPRY2
May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
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Protein names
Recommended name:
Protein sprouty homolog 2Alternative name(s):
Spry-2- RS171156 (SPRY2) ??
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Top Gene-Substance Interactions
SPRY2 Interacts with These Diseases
| Disease | Score |
Substances That Increase SPRY2
| Substances | Interaction | Organism | Category |
Substances That Decrease SPRY2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
By FGF signaling.
Molecular Function:
- Protein Kinase Binding
- Protein Serine/Threonine Kinase Activator Activity
- Protein Serine/Threonine Kinase Inhibitor Activity
Biological Processes:
- Bud Elongation Involved In Lung Branching
- Cell Fate Commitment
- Establishment Of Mitotic Spindle Orientation
- Inner Ear Morphogenesis
- Lung Growth
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Cell Projection Organization
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
- Negative Regulation Of Erk1 And Erk2 Cascade
- Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
- Negative Regulation Of Gtpase Activity
- Negative Regulation Of Map Kinase Activity
- Negative Regulation Of Neurotrophin Trk Receptor Signaling Pathway
- Negative Regulation Of Peptidyl-Threonine Phosphorylation
- Negative Regulation Of Ras Protein Signal Transduction
- Positive Regulation Of Erk1 And Erk2 Cascade
- Positive Regulation Of Gene Expression
- Positive Regulation Of Peptidyl-Serine Phosphorylation
- Positive Regulation Of Protein Kinase B Signaling
- Regulation Of Cell Differentiation
- Sensory Perception Of Sound