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  3. SPRY2

SPRY2 (Sprouty RTK signaling antagonist 2)

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The Function of SPRY2

May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

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Protein names

Recommended name:

Protein sprouty homolog 2

Alternative name(s):

Spry-2

SPRY2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS171156 (SPRY2) ??

Top Gene-Substance Interactions

SPRY2 Interacts with These Diseases

Disease Score

Substances That Increase SPRY2

Substances Interaction Organism Category

Substances That Decrease SPRY2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

Gene Pathways:

  • Disease
  • Signal Transduction
  • Jak-STAT signaling pathway

Induction:

By FGF signaling.

Molecular Function:

  • Protein Kinase Binding
  • Protein Serine/Threonine Kinase Activator Activity
  • Protein Serine/Threonine Kinase Inhibitor Activity

Biological Processes:

  • Bud Elongation Involved In Lung Branching
  • Cell Fate Commitment
  • Establishment Of Mitotic Spindle Orientation
  • Inner Ear Morphogenesis
  • Lung Growth
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Cell Projection Organization
  • Negative Regulation Of Cell Proliferation
  • Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
  • Negative Regulation Of Erk1 And Erk2 Cascade
  • Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
  • Negative Regulation Of Gtpase Activity
  • Negative Regulation Of Map Kinase Activity
  • Negative Regulation Of Neurotrophin Trk Receptor Signaling Pathway
  • Negative Regulation Of Peptidyl-Threonine Phosphorylation
  • Negative Regulation Of Ras Protein Signal Transduction
  • Positive Regulation Of Erk1 And Erk2 Cascade
  • Positive Regulation Of Gene Expression
  • Positive Regulation Of Peptidyl-Serine Phosphorylation
  • Positive Regulation Of Protein Kinase B Signaling
  • Regulation Of Cell Differentiation
  • Sensory Perception Of Sound
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| putative protein sprouty-like protein| Anapl_13959| AS27_08796| AS28_15108| CB1_000594020| D623_10018225| EGK_09395| GW7_19321| H920_04552| hSPRY2| IGAN3| M959_00711| MDA_GLEAN10008923| N300_11086| N301_00218| N302_02108| N303_12407| N305_13113| N306_01007| N307_07450| N308_15121| N309_05585| N310_09941| N311_04137| N312_06932| N320_02396| N321_03628| N322_10535| N324_07377| N325_00797| N326_00749| N327_07564| N328_06111| N329_04454| N330_05681| N331_05364| N332_03817| N333_04980| N334_07510| N335_02134| N336_10545| N339_05908| PAL_GLEAN10020381| PANDA_008701| Protein sprouty 2| protein sprouty 2 isoform 1-like protein| protein sprouty homolog 2| Protein sprouty-like 2| Protein sprouty like protein 2| Protein sprouty-like protein 2| sprouty2| sprouty 2| sprouty-2| sprouty homolog 2| sprouty homolog 2 (Drosophila)| sprouty-like protein 2| spry-2| TREES_T100004815| UY3_08412| Xsprouty2| xspry2| Xtsprouty2| Y956_04696| Z169_15526| spry2

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