The Function of SPRY1
May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
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Protein names
Recommended name:
Protein sprouty homolog 1Alternative name(s):
Spry-1Top Gene-Substance Interactions
Substances That Increase SPRY1
| Substances | Interaction | Organism | Category |
Substances That Decrease SPRY1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Induction:
By FGF signaling.
Biological Processes:
- Bud Elongation Involved In Lung Branching
- Establishment Of Mitotic Spindle Orientation
- Metanephros Development
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
- Negative Regulation Of Erk1 And Erk2 Cascade
- Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
- Negative Regulation Of Gtpase Activity
- Negative Regulation Of Map Kinase Activity
- Negative Regulation Of Neurotrophin Trk Receptor Signaling Pathway
- Negative Regulation Of Ras Protein Signal Transduction
- Organ Induction
- Ureteric Bud Development