The Function of SPP1
Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.
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Protein names
Recommended name:
OsteopontinShort name:
SPP-1Alternative name(s):
Bone sialoprotein 1Nephropontin
Secreted phosphoprotein 1
Urinary stone protein
Uropontin
- RS1126616 (SPP1) ??
- RS1126772 (SPP1) ??
- RS11728697 (SPP1) ??
- RS11730582 (SPP1) ??
- RS2725236 (SPP1) ??
- RS28357094 (SPP1) ??
- RS4754 (SPP1) ??
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Top Gene-Substance Interactions
SPP1 Interacts with These Diseases
| Disease | Score |
Substances That Increase SPP1
| Substances | Interaction | Organism | Category |
Substances That Decrease SPP1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Bone. Found in plasma.
Gene Pathways:
Molecular Function:
Biological Processes:
- Osteoblast Differentiation
- Inflammatory Response
- Cell Adhesion
- Embryo Implantation
- Extracellular Matrix Disassembly
- Extracellular Matrix Organization
- Biomineral Tissue Development
- Response To Vitamin D
- Positive Regulation Of Bone Resorption
- Decidualization
- Response To Steroid Hormone
- Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury