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  3. SPP1

SPP1 (Secreted phosphoprotein 1)

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The Function of SPP1

Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.

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Protein names

Recommended name:

Osteopontin

Short name:

SPP-1

Alternative name(s):

Bone sialoprotein 1
Nephropontin
Secreted phosphoprotein 1
Urinary stone protein
Uropontin

SPP1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1126616 (SPP1) ??
  2. RS1126772 (SPP1) ??
  3. RS11728697 (SPP1) ??
  4. RS11730582 (SPP1) ??
  5. RS2725236 (SPP1) ??
  6. RS28357094 (SPP1) ??
  7. RS4754 (SPP1) ??

Top Gene-Substance Interactions

SPP1 Interacts with These Diseases

Disease Score

Substances That Increase SPP1

Substances Interaction Organism Category

Substances That Decrease SPP1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • GR
  • GR-alpha
  • GR-beta
  • AP-1
  • c-Jun
  • c-Myc
  • Sp1
  • c-Fos

Tissue specificity:

Bone. Found in plasma.

Gene Pathways:

  • Signal Transduction
  • Toll-like receptor signaling pathway
  • Extracellular matrix organization

Molecular Function:

  • Extracellular Matrix Binding

Biological Processes:

  • Biomineral Tissue Development
  • Cell Adhesion
  • Decidualization
  • Embryo Implantation
  • Extracellular Matrix Disassembly
  • Extracellular Matrix Organization
  • Inflammatory Response
  • Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
  • Osteoblast Differentiation
  • Positive Regulation Of Bone Resorption
  • Response To Steroid Hormone
  • Response To Vitamin D
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| OSP| OC-1| OST| 2AR| 44 kDa bone phosphoprotein| A306_06576| Apl-1| AS27_05725| AS28_03139| BNSP| Bone sialoprotein 1| bone sialoprotein I| Bsp| BSPI| calcium oxalate crystal growth inhibitor protein| CB1_000209003| early T-lymphocyte activation 1| early T-lymphocyte activation 1 protein| EGK_21234| Eta| ETA-1| GW7_20316| H920_16096| I79_024462| M959_04882| MDA_GLEAN10007996| minopontin| N300_03086| N301_03959| N302_06063| N303_09479| N305_05236| N306_01169| N307_02114| N308_05678| N309_00770| N310_05045| N311_10544| N312_08136| N320_10802| N321_14116| N322_03601| N324_10950| N325_05356| N326_05278| N327_11822| N328_11481| N329_02073| N330_00653| N331_02046| N333_04924| N334_04865| N335_07655| N336_06439| N339_06353| N340_03835| N341_09912| nephropontin| OP| OPN| Opnl| Osteopontin| osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein| osteopontin isoform OPN-a| osteopontin isoform OPN-c| osteopontin-K| osteopontin-like protein| PAL_GLEAN10010907| PANDA_001445| Ric| secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)| secreted phosphoprotein 1 variant 6| Sialoprotein (osteopontin)| Spp-1| SPP1/CALPHA1 fusion| spp1 protein| TREES_T100011616| urinary stone protein| uropontin| UY3_13551| Y1Q_002941| Y956_11704| Z169_13679| spp1

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