The Function of SPINK1
In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.
Protein names
Recommended name:
Serine protease inhibitor Kazal-type 1Short name:
TATIAlternative name(s):
Pancreatic secretory trypsin inhibitorTumor-associated trypsin inhibitor
- RS17107315 (SPINK1) ??
- RS891992 (SPINK1) ??
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Top Gene-Substance Interactions
SPINK1 Interacts with These Diseases
| Disease | Score |
Substances That Increase SPINK1
| Substances | Interaction | Organism | Category |
Substances That Decrease SPINK1
| Substances | Interaction | Organism | Category |
Advanced Summary
Covered on Genetics Home Reference: hereditary pancreatitisFrom NCBI Gene: Hereditary pancreatitisTropical calcific pancreatitisFrom UniProt: Tropical calcific pancreatitis (TCP): Idiopathic, juvenile, nonalcoholic form of chronic pancreatitis widely prevalent in several tropical countries. It can be associated with fibrocalculous pancreatic diabetes (FCPD) depending on both environmental and genetic factors. TCP differs from alcoholic pancreatitis by a much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant diabetes mellitus, and an exceptionally high incidence of pancreatic cancer. [MIM:608189] Pancreatitis, hereditary (PCTT): A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks. [MIM:167800]
From NCBI Gene: The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. [provided by RefSeq, Oct 2008] From UniProt: Serine protease inhibitor which exhibits anti-trypsin activity (PubMed:7142173). In the pancreas, protects against trypsin-catalyzed premature activation of zymogens. In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Molecular Function:
Biological Processes:
- Negative Regulation Of Calcium Ion Import
- Negative Regulation Of Nitric Oxide Mediated Signal Transduction
- Negative Regulation Of Peptidyl-Tyrosine Phosphorylation
- Negative Regulation Of Serine-Type Endopeptidase Activity
- Regulation Of Acrosome Reaction
- Regulation Of Store-Operated Calcium Entry