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  3. SPINK1

SPINK1 (Serine peptidase inhibitor, Kazal type 1)

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The Function of SPINK1

In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.

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Protein names

Recommended name:

Serine protease inhibitor Kazal-type 1

Short name:

TATI

Alternative name(s):

Pancreatic secretory trypsin inhibitor
Tumor-associated trypsin inhibitor

SPINK1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS17107315 (SPINK1) ??
  2. RS891992 (SPINK1) ??

Top Gene-Substance Interactions

SPINK1 Interacts with These Diseases

Disease Score

Substances That Increase SPINK1

Substances Interaction Organism Category

Substances That Decrease SPINK1

Substances Interaction Organism Category

Advanced Summary

     Covered on Genetics Home Reference: hereditary pancreatitisFrom NCBI Gene: Hereditary pancreatitisTropical calcific pancreatitisFrom UniProt: Tropical calcific pancreatitis (TCP): Idiopathic, juvenile, nonalcoholic form of chronic pancreatitis widely prevalent in several tropical countries. It can be associated with fibrocalculous pancreatic diabetes (FCPD) depending on both environmental and genetic factors. TCP differs from alcoholic pancreatitis by a much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant diabetes mellitus, and an exceptionally high incidence of pancreatic cancer. [MIM:608189] Pancreatitis, hereditary (PCTT): A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks. [MIM:167800]

     From NCBI Gene: The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. [provided by RefSeq, Oct 2008] From UniProt: Serine protease inhibitor which exhibits anti-trypsin activity (PubMed:7142173). In the pancreas, protects against trypsin-catalyzed premature activation of zymogens. In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1

Molecular Function:

  • Endopeptidase Inhibitor Activity
  • Serine-Type Endopeptidase Inhibitor Activity

Biological Processes:

  • Negative Regulation Of Calcium Ion Import
  • Negative Regulation Of Nitric Oxide Mediated Signal Transduction
  • Negative Regulation Of Peptidyl-Tyrosine Phosphorylation
  • Negative Regulation Of Serine-Type Endopeptidase Activity
  • Regulation Of Acrosome Reaction
  • Regulation Of Store-Operated Calcium Entry
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

p12| calcium transport inhibitor| caltrin| AS27_11956| AS28_10595| EGK_16991| H920_06552| N300_12987| N301_00612| N327_12823| N328_12944| N333_13584| N334_03790| N336_05998| Pancreatic secretory trypsin inhibitor| pancreatic secretory trypsin inhibitor II| pancreatic secretory trypsin inhibitor type II (PSTI-II)| PANDA_020598| PCTT| prostatic secretory glycoprotein| PSTI| PSTI-II| serine peptidase inhibitor, Kazal type 3| serine protease inhibitor Kazal-type 1| serine protease inhibitor, Kazal type 1| serine protease inhibitor Kazal-type 1-like| serine protease inhibitor Kazal-type 3| Spink1l| Spink3| TATI| TCP| tumor-associated trypsin inhibitor| spink1

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