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  3. SPHK2

SPHK2 (Sphingosine kinase 2)

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The Function of SPHK2

Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides.

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Protein names

Recommended name:

Sphingosine kinase 2

Short name:

SK 2

Alternative name(s):

SPK 2

Top Gene-Substance Interactions

SPHK2 Interacts with These Diseases

Disease Score

Substances That Increase SPHK2

Substances Interaction Organism Category

Substances That Decrease SPHK2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • STAT5A

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Calcium signaling pathway
  • Tuberculosis
  • VEGF signaling pathway
  • Sphingolipid metabolism

Enzyme Regulation:

Inhibited by sulfatide.

Molecular Function:

  • Atp Binding
  • D-Erythro-Sphingosine Kinase Activity
  • Ras Gtpase Binding
  • Sphinganine Kinase Activity
  • Sphingosine-1-Phosphate Receptor Activity

Biological Processes:

  • Blood Vessel Development
  • Brain Development
  • Cell Proliferation
  • Female Pregnancy
  • Negative Regulation Of Apoptotic Process
  • Positive Regulation Of Cell Proliferation
  • Sphinganine-1-Phosphate Biosynthetic Process
  • Sphingolipid Biosynthetic Process
  • Sphingosine Biosynthetic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| SK 2| C76851| CB1_007371006| EGK_10845| H920_12398| M91_16029| MDA_GLEAN10005934| PAL_GLEAN10004591| PANDA_006315| SK-2| Sphingosine kinase 1| sphingosine kinase 2-like protein| sphingosine kinase type 2| SPK 2| SPK-2| Spk2, Sk2| TREES_T100015197| UY3_14095| Y1Q_014951| sphk2

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