The Function of SPHK2
Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides.
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Protein names
Recommended name:
Sphingosine kinase 2Short name:
SK 2Alternative name(s):
SPK 2Top Gene-Substance Interactions
SPHK2 Interacts with These Diseases
| Disease | Score |
Substances That Increase SPHK2
| Substances | Interaction | Organism | Category |
Substances That Decrease SPHK2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Enzyme Regulation:
Inhibited by sulfatide.
Molecular Function:
- Atp Binding
- D-Erythro-Sphingosine Kinase Activity
- Ras Gtpase Binding
- Sphinganine Kinase Activity
- Sphingosine-1-Phosphate Receptor Activity
Biological Processes:
- Blood Vessel Development
- Brain Development
- Cell Proliferation
- Female Pregnancy
- Negative Regulation Of Apoptotic Process
- Positive Regulation Of Cell Proliferation
- Sphinganine-1-Phosphate Biosynthetic Process
- Sphingolipid Biosynthetic Process
- Sphingosine Biosynthetic Process