The Function of SOX9
Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.
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Protein names
Recommended name:
Transcription factor SOX-9- RS9915657 (SOX9) ??
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Top Gene-Substance Interactions
SOX9 Interacts with These Diseases
| Disease | Score |
Substances That Increase SOX9
| Substances | Interaction | Organism | Category |
Substances That Decrease SOX9
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Molecular Function:
- Core Promoter Sequence-Specific Dna Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Enhancer Sequence-Specific Dna Binding
- Chromatin Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
- Protein Kinase A Catalytic Subunit Binding
- Enhancer Binding
- Pre-Mrna Intronic Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Skeletal System Development
- Cartilage Condensation
- Ossification
- Branching Involved In Ureteric Bud Morphogenesis
- Cell Fate Specification
- Epithelial To Mesenchymal Transition
- Tissue Homeostasis
- Positive Regulation Of Protein Phosphorylation
- Hair Follicle Development
- Positive Regulation Of Mesenchymal Cell Proliferation
- Negative Regulation Of Immune System Process
- Heart Valve Development
- Heart Valve Morphogenesis
- Heart Valve Formation
- Endocardial Cushion Morphogenesis
- Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis
- Chondrocyte Hypertrophy
- Nucleosome Assembly
- Chromatin Remodeling
- Protein Complex Assembly
- Cytoskeleton Organization
- Signal Transduction
- Epidermal Growth Factor Receptor Signaling Pathway
- Notch Signaling Pathway
- Spermatogenesis
- Positive Regulation Of Cell Proliferation
- Male Gonad Development
- Regulation Of Cell Cycle Process
- Positive Regulation Of Epithelial Cell Migration
- Neural Crest Cell Development
- Positive Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Single Organismal Cell-Cell Adhesion
- Male Germ-Line Sex Determination
- Camp-Mediated Signaling
- Regulation Of Cell Adhesion
- Extracellular Matrix Organization
- Negative Regulation Of Ossification
- Negative Regulation Of Bone Mineralization
- Prostate Gland Development
- Negative Regulation Of Epithelial Cell Differentiation
- Positive Regulation Of Epithelial Cell Differentiation
- Mammary Gland Development
- Notochord Development
- Otic Vesicle Formation
- Endocrine Pancreas Development
- Negative Regulation Of Chondrocyte Differentiation
- Positive Regulation Of Chondrocyte Differentiation
- Lacrimal Gland Development
- Protein Localization To Nucleus
- Somatic Stem Cell Population Maintenance
- Intrahepatic Bile Duct Development
- Regulation Of Cell Proliferation
- Regulation Of Apoptotic Process
- Negative Regulation Of Apoptotic Process
- Protein Kinase B Signaling
- Negative Regulation Of Myoblast Differentiation
- Positive Regulation Of Protein Catabolic Process
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Negative Regulation Of Photoreceptor Cell Differentiation
- Oligodendrocyte Differentiation
- Positive Regulation Of Epithelial Cell Proliferation
- Negative Regulation Of Epithelial Cell Proliferation
- Cartilage Development
- Sertoli Cell Differentiation
- Sertoli Cell Development
- Astrocyte Fate Commitment
- Retina Development In Camera-Type Eye
- Limb Bud Formation
- Retinal Rod Cell Differentiation
- Epithelial Tube Branching Involved In Lung Morphogenesis
- Lung Epithelial Cell Differentiation
- Epithelial Cell Proliferation Involved In Prostatic Bud Elongation
- Bronchus Cartilage Development
- Trachea Cartilage Development
- Intestinal Epithelial Structure Maintenance
- Regulation Of Cell Proliferation Involved In Tissue Homeostasis
- Positive Regulation Of Cartilage Development
- Regulation Of Branching Involved In Lung Morphogenesis
- Morphogenesis Of A Branching Epithelium
- Lung Smooth Muscle Development
- Negative Regulation Of Biomineral Tissue Development
- Erk1 And Erk2 Cascade
- Harderian Gland Development
- Cellular Response To Mechanical Stimulus
- Cellular Response To Retinoic Acid
- Cellular Response To Interleukin-1
- Cellular Response To Epidermal Growth Factor Stimulus
- Cellular Response To Heparin
- Cellular Response To Transforming Growth Factor Beta Stimulus
- Renal Vesicle Induction
- Ureter Urothelium Development
- Ureter Smooth Muscle Cell Differentiation
- Ureter Morphogenesis
- Metanephric Nephron Tubule Formation
- Negative Regulation Of Canonical Wnt Signaling Pathway
- Cochlea Morphogenesis
- Positive Regulation Of Kidney Development
- Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
- Positive Regulation Of Extracellular Matrix Assembly
- Negative Regulation Of Pri-Mirna Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Male Gonad Development
- Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis
- Positive Regulation Of Mesenchymal Stem Cell Differentiation
- Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
- Negative Regulation Of Mesenchymal Cell Apoptotic Process