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  2. Genes
  3. SOX9

SOX9 (SRY-box 9)

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The Function of SOX9

Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.

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Protein names

Recommended name:

Transcription factor SOX-9

SOX9 SNPs

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  1. RS9915657 (SOX9) ??

Top Gene-Substance Interactions

SOX9 Interacts with These Diseases

Disease Score

Substances That Increase SOX9

Substances Interaction Organism Category

Substances That Decrease SOX9

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CREB
  • deltaCREB
  • Sp1
  • Sox9
  • p300
  • Sox5

Molecular Function:

  • Core Promoter Sequence-Specific Dna Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Enhancer Sequence-Specific Dna Binding
  • Chromatin Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
  • Protein Kinase A Catalytic Subunit Binding
  • Enhancer Binding
  • Pre-Mrna Intronic Binding

Biological Processes:

  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Skeletal System Development
  • Cartilage Condensation
  • Ossification
  • Branching Involved In Ureteric Bud Morphogenesis
  • Cell Fate Specification
  • Epithelial To Mesenchymal Transition
  • Tissue Homeostasis
  • Positive Regulation Of Protein Phosphorylation
  • Hair Follicle Development
  • Positive Regulation Of Mesenchymal Cell Proliferation
  • Negative Regulation Of Immune System Process
  • Heart Valve Development
  • Heart Valve Morphogenesis
  • Heart Valve Formation
  • Endocardial Cushion Morphogenesis
  • Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis
  • Chondrocyte Hypertrophy
  • Nucleosome Assembly
  • Chromatin Remodeling
  • Protein Complex Assembly
  • Cytoskeleton Organization
  • Signal Transduction
  • Epidermal Growth Factor Receptor Signaling Pathway
  • Notch Signaling Pathway
  • Spermatogenesis
  • Positive Regulation Of Cell Proliferation
  • Male Gonad Development
  • Regulation Of Cell Cycle Process
  • Positive Regulation Of Epithelial Cell Migration
  • Neural Crest Cell Development
  • Positive Regulation Of Phosphatidylinositol 3-Kinase Signaling
  • Single Organismal Cell-Cell Adhesion
  • Male Germ-Line Sex Determination
  • Camp-Mediated Signaling
  • Regulation Of Cell Adhesion
  • Extracellular Matrix Organization
  • Negative Regulation Of Ossification
  • Negative Regulation Of Bone Mineralization
  • Prostate Gland Development
  • Negative Regulation Of Epithelial Cell Differentiation
  • Positive Regulation Of Epithelial Cell Differentiation
  • Mammary Gland Development
  • Notochord Development
  • Otic Vesicle Formation
  • Endocrine Pancreas Development
  • Negative Regulation Of Chondrocyte Differentiation
  • Positive Regulation Of Chondrocyte Differentiation
  • Lacrimal Gland Development
  • Protein Localization To Nucleus
  • Somatic Stem Cell Population Maintenance
  • Intrahepatic Bile Duct Development
  • Regulation Of Cell Proliferation
  • Regulation Of Apoptotic Process
  • Negative Regulation Of Apoptotic Process
  • Protein Kinase B Signaling
  • Negative Regulation Of Myoblast Differentiation
  • Positive Regulation Of Protein Catabolic Process
  • Negative Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Negative Regulation Of Photoreceptor Cell Differentiation
  • Oligodendrocyte Differentiation
  • Positive Regulation Of Epithelial Cell Proliferation
  • Negative Regulation Of Epithelial Cell Proliferation
  • Cartilage Development
  • Sertoli Cell Differentiation
  • Sertoli Cell Development
  • Astrocyte Fate Commitment
  • Retina Development In Camera-Type Eye
  • Limb Bud Formation
  • Retinal Rod Cell Differentiation
  • Epithelial Tube Branching Involved In Lung Morphogenesis
  • Lung Epithelial Cell Differentiation
  • Epithelial Cell Proliferation Involved In Prostatic Bud Elongation
  • Bronchus Cartilage Development
  • Trachea Cartilage Development
  • Intestinal Epithelial Structure Maintenance
  • Regulation Of Cell Proliferation Involved In Tissue Homeostasis
  • Positive Regulation Of Cartilage Development
  • Regulation Of Branching Involved In Lung Morphogenesis
  • Morphogenesis Of A Branching Epithelium
  • Lung Smooth Muscle Development
  • Negative Regulation Of Biomineral Tissue Development
  • Erk1 And Erk2 Cascade
  • Harderian Gland Development
  • Cellular Response To Mechanical Stimulus
  • Cellular Response To Retinoic Acid
  • Cellular Response To Interleukin-1
  • Cellular Response To Epidermal Growth Factor Stimulus
  • Cellular Response To Heparin
  • Cellular Response To Transforming Growth Factor Beta Stimulus
  • Renal Vesicle Induction
  • Ureter Urothelium Development
  • Ureter Smooth Muscle Cell Differentiation
  • Ureter Morphogenesis
  • Metanephric Nephron Tubule Formation
  • Cochlea Morphogenesis
  • Negative Regulation Of Canonical Wnt Signaling Pathway
  • Positive Regulation Of Kidney Development
  • Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
  • Positive Regulation Of Extracellular Matrix Assembly
  • Negative Regulation Of Pri-Mirna Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Male Gonad Development
  • Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis
  • Positive Regulation Of Mesenchymal Stem Cell Differentiation
  • Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
  • Negative Regulation Of Mesenchymal Cell Apoptotic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| SRA1| A306_11647| AS27_15192| AS28_11773| AV220920| CB1_000245030| cmd1| cmpd1| GW7_01540| H920_12296| I79_000973| MDA_GLEAN10015890| N300_05040| N302_09315| N307_13003| N309_04463| PAL_GLEAN10014806| PsSox9| sex determining region Y-box 9| sex determining region Y-box 9 protein| SOX-9| SOX9 alpha2| SRXX2| SRXY10| SRY| SRY box 9| SRY-box containing 9| SRY-box containing gene 9| SRY-box containing gene 9 homologue| SRY-box containing protein 9| SRY-related HMG-box, gene 9| Sry-related HMG-box protein 9| SRY (sex determining region Y)-box9| SRY (sex determining region Y)-box 9| SRY sex determining region Y-box 9| SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)| SRY (sex-determining region Y)-box 9 protein| transcription activator Sox9| Transcription factor SOX-10| transcription factor Sox-9| transcription factor SOX9| transcription factor SOX9a| Transcription factor Sox-9-B| TREES_T100007271| UY3_03491| xt-sox9| Y1Q_011655| Y956_08455| sox9

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