The Function of SOX17
Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells.
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Protein names
Recommended name:
Transcription factor SOX-17Top Gene-Substance Interactions
SOX17 Interacts with These Diseases
| Disease | Score |
Substances That Increase SOX17
| Substances | Interaction | Organism | Category |
Substances That Decrease SOX17
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in adult heart, lung, spleen, testis, ovary, placenta, fetal lung, and kidney. In normal gastrointestinal tract, it is preferentially expressed in esophagus, stomach and small intestine than in colon and rectum.
Gene Pathways:
Molecular Function:
- Transcriptional Activator Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
- Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
- Transcription Coactivator Activity
- Beta-Catenin Binding
- Transcription Factor Binding
- Sequence-Specific Dna Binding
- Transcription Regulatory Region Dna Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Angiogenesis
- Vasculogenesis
- Endoderm Formation
- Inner Cell Mass Cellular Morphogenesis
- Heart Looping
- Cardiogenic Plate Morphogenesis
- Embryonic Heart Tube Morphogenesis
- Outflow Tract Morphogenesis
- Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development
- Regulation Of Transcription, Dna-Templated
- Spermatogenesis
- Endodermal Cell Fate Determination
- Rostrocaudal Neural Tube Patterning
- Signal Transduction Involved In Regulation Of Gene Expression
- Negative Regulation Of Cell Growth
- Protein Destabilization
- Embryonic Heart Tube Development
- Cell Migration Involved In Gastrulation
- Negative Regulation Of Mesodermal Cell Fate Specification
- Mrna Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Cell Differentiation
- Positive Regulation Of Protein Catabolic Process
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Embryonic Development
- Embryonic Foregut Morphogenesis
- Positive Regulation Of Skeletal Muscle Tissue Development
- Stem Cell Fate Specification
- Protein Stabilization
- Canonical Wnt Signaling Pathway
- Endocardium Formation
- Regulation Of Transcription From Rna Polymerase Ii Promoter Involved In Definitive Endodermal Cell Fate Specification
- Cardiac Cell Fate Determination
- Heart Formation
- Endocardial Cell Differentiation
- Common Bile Duct Development
- Gall Bladder Development
- Endodermal Digestive Tract Morphogenesis
- Renal System Development
- Regulation Of Stem Cell Proliferation
- Negative Regulation Of Canonical Wnt Signaling Pathway
- Regulation Of Stem Cell Division
- Regulation Of Cardiac Cell Fate Specification