The Function of SOX17
Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells.
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Protein names
Recommended name:
Transcription factor SOX-17Top Gene-Substance Interactions
SOX17 Interacts with These Diseases
| Disease | Score |
Substances That Increase SOX17
| Substances | Interaction | Organism | Category |
Substances That Decrease SOX17
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in adult heart, lung, spleen, testis, ovary, placenta, fetal lung, and kidney. In normal gastrointestinal tract, it is preferentially expressed in esophagus, stomach and small intestine than in colon and rectum.
Gene Pathways:
Molecular Function:
- Beta-Catenin Binding
- Sequence-Specific Dna Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
- Transcription Coactivator Activity
- Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
- Transcription Factor Binding
- Transcription Regulatory Region Dna Binding
Biological Processes:
- Angiogenesis
- Canonical Wnt Signaling Pathway
- Cardiac Cell Fate Determination
- Cardiogenic Plate Morphogenesis
- Cell Migration Involved In Gastrulation
- Common Bile Duct Development
- Embryonic Foregut Morphogenesis
- Embryonic Heart Tube Development
- Embryonic Heart Tube Morphogenesis
- Endocardial Cell Differentiation
- Endocardium Formation
- Endodermal Cell Fate Determination
- Endodermal Digestive Tract Morphogenesis
- Endoderm Formation
- Gall Bladder Development
- Heart Formation
- Heart Looping
- Inner Cell Mass Cellular Morphogenesis
- Mrna Transcription From Rna Polymerase Ii Promoter
- Negative Regulation Of Canonical Wnt Signaling Pathway
- Negative Regulation Of Cell Growth
- Negative Regulation Of Mesodermal Cell Fate Specification
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development
- Outflow Tract Morphogenesis
- Positive Regulation Of Cell Differentiation
- Positive Regulation Of Protein Catabolic Process
- Positive Regulation Of Skeletal Muscle Tissue Development
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Protein Destabilization
- Protein Stabilization
- Regulation Of Cardiac Cell Fate Specification
- Regulation Of Embryonic Development
- Regulation Of Stem Cell Division
- Regulation Of Stem Cell Proliferation
- Regulation Of Transcription, Dna-Templated
- Regulation Of Transcription From Rna Polymerase Ii Promoter Involved In Definitive Endodermal Cell Fate Specification
- Renal System Development
- Rostrocaudal Neural Tube Patterning
- Signal Transduction Involved In Regulation Of Gene Expression
- Spermatogenesis
- Stem Cell Fate Specification
- Vasculogenesis