• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. SOX17

SOX17 (SRY-box 17)

Loading...

The Function of SOX17

Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Transcription factor SOX-17

Top Gene-Substance Interactions

SOX17 Interacts with These Diseases

Disease Score

Substances That Increase SOX17

Substances Interaction Organism Category

Substances That Decrease SOX17

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Nkx2-5
  • HNF-4alpha1
  • HNF-4alpha2
  • HFH-1
  • GATA-6

Tissue specificity:

Expressed in adult heart, lung, spleen, testis, ovary, placenta, fetal lung, and kidney. In normal gastrointestinal tract, it is preferentially expressed in esophagus, stomach and small intestine than in colon and rectum.

Gene Pathways:

  • Wnt signaling pathway

Molecular Function:

  • Beta-Catenin Binding
  • Sequence-Specific Dna Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
  • Transcription Coactivator Activity
  • Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
  • Transcription Factor Binding
  • Transcription Regulatory Region Dna Binding

Biological Processes:

  • Angiogenesis
  • Canonical Wnt Signaling Pathway
  • Cardiac Cell Fate Determination
  • Cardiogenic Plate Morphogenesis
  • Cell Migration Involved In Gastrulation
  • Common Bile Duct Development
  • Embryonic Foregut Morphogenesis
  • Embryonic Heart Tube Development
  • Embryonic Heart Tube Morphogenesis
  • Endocardial Cell Differentiation
  • Endocardium Formation
  • Endodermal Cell Fate Determination
  • Endodermal Digestive Tract Morphogenesis
  • Endoderm Formation
  • Gall Bladder Development
  • Heart Formation
  • Heart Looping
  • Inner Cell Mass Cellular Morphogenesis
  • Mrna Transcription From Rna Polymerase Ii Promoter
  • Negative Regulation Of Canonical Wnt Signaling Pathway
  • Negative Regulation Of Cell Growth
  • Negative Regulation Of Mesodermal Cell Fate Specification
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development
  • Outflow Tract Morphogenesis
  • Positive Regulation Of Cell Differentiation
  • Positive Regulation Of Protein Catabolic Process
  • Positive Regulation Of Skeletal Muscle Tissue Development
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Protein Destabilization
  • Protein Stabilization
  • Regulation Of Cardiac Cell Fate Specification
  • Regulation Of Embryonic Development
  • Regulation Of Stem Cell Division
  • Regulation Of Stem Cell Proliferation
  • Regulation Of Transcription, Dna-Templated
  • Regulation Of Transcription From Rna Polymerase Ii Promoter Involved In Definitive Endodermal Cell Fate Specification
  • Renal System Development
  • Rostrocaudal Neural Tube Patterning
  • Signal Transduction Involved In Regulation Of Gene Expression
  • Spermatogenesis
  • Stem Cell Fate Specification
  • Vasculogenesis
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

H920_18115| HMG transcription factor SOX17| N325_03595| PAL_GLEAN10019250| SRY box 17| SRY-box containing gene 17| SRY-box containing transcription factor 17| SRY-related HMG-box transcription factor SOX17| SRY (sex determining region Y)-box 17| transcription factor Sox17| Transcription factor SOX-17| Transcription factor Sox-7| TREES_T100010488| VUR3| sox17

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved