The Function of SOX11
Transcriptional factor involved in the embryonic neurogenesis. May also have a role in tissue modeling during development.
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Protein names
Recommended name:
Transcription factor SOX-11- RS16864170 (SOX11) ??
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Top Gene-Substance Interactions
SOX11 Interacts with These Diseases
| Disease | Score |
Substances That Increase SOX11
| Substances | Interaction | Organism | Category |
Substances That Decrease SOX11
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed mainly in the nervous system, brain (fetus and adult) and hear (adult).
Molecular Function:
- Transcription Regulatory Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Core Promoter Sequence-Specific Dna Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Rna Polymerase Ii Transcription Coactivator Activity
- Enhancer Sequence-Specific Dna Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Translation Factor Activity, Rna Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Skeletal System Development
- Kidney Development
- Neural Tube Formation
- Lens Morphogenesis In Camera-Type Eye
- Outflow Tract Morphogenesis
- Cardiac Ventricle Formation
- Noradrenergic Neuron Differentiation
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Gene Expression
- Negative Regulation Of Gene Expression
- Oligodendrocyte Development
- Glial Cell Proliferation
- Neural Crest Cell Development
- Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
- Spinal Cord Development
- Glial Cell Development
- Neuron Differentiation
- Positive Regulation Of Bmp Signaling Pathway
- Positive Regulation Of Hippo Signaling
- Skeletal Muscle Cell Differentiation
- Positive Regulation Of Neuron Differentiation
- Positive Regulation Of Osteoblast Differentiation
- Positive Regulation Of Ossification
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Hormone Secretion
- Sympathetic Nervous System Development
- Embryonic Digestive Tract Morphogenesis
- Embryonic Skeletal System Morphogenesis
- Negative Regulation Of Lymphocyte Proliferation
- Positive Regulation Of Neurogenesis
- Hard Palate Development
- Soft Palate Development
- Limb Bud Formation
- Negative Regulation Of Glial Cell Proliferation
- Ventricular Septum Morphogenesis
- Lung Morphogenesis
- Negative Regulation Of Cell Death
- Neuroepithelial Cell Differentiation
- Eyelid Development In Camera-Type Eye
- Somite Development
- Cornea Development In Camera-Type Eye
- Closure Of Optic Fissure
- Signal Transduction Involved In Cell Cycle Checkpoint
- Positive Regulation Of Stem Cell Proliferation
- Negative Regulation Of Transcription Regulatory Region Dna Binding
- Positive Regulation Of Lens Epithelial Cell Proliferation