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  3. SOCS1

SOCS1 (Suppressor of cytokine signaling 1)

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The Function of SOCS1

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

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Protein names

Recommended name:

Suppressor of cytokine signaling 1

Short name:

JAB

Alternative name(s):

SOCS-1
JAK-binding protein
STAT-induced STAT inhibitor 1
SSI-1
Tec-interacting protein 3
TIP-3

Top Gene-Substance Interactions

SOCS1 Interacts with These Diseases

Disease Score

Substances That Increase SOCS1

Substances Interaction Organism Category

Substances That Decrease SOCS1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • Egr-1
  • STAT3
  • NF-kappaB1
  • SREBP-1a
  • STAT6
  • SREBP-1c
  • SREBP-1b
  • GATA-3
  • RelA

Tissue specificity:

Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.

Gene Pathways:

  • Immune System
  • Signal Transduction
  • Jak-STAT signaling pathway
  • Insulin signaling pathway
  • Osteoclast differentiation
  • Toxoplasmosis
  • Type II diabetes mellitus
  • Ubiquitin mediated proteolysis

Induction:

By a subset of cytokines including those belonging to the interferon, interleukin and colony-stimulating factor families.

Molecular Function:

  • Insulin-Like Growth Factor Receptor Binding
  • Kinase Inhibitor Activity
  • Protein Kinase Binding
  • Protein Kinase Inhibitor Activity

Biological Processes:

  • Cellular Response To Amino Acid Stimulus
  • Cytokine-Mediated Signaling Pathway
  • Fat Cell Differentiation
  • Jak-Stat Cascade
  • Negative Regulation Of Insulin Receptor Signaling Pathway
  • Negative Regulation Of Jak-Stat Cascade
  • Negative Regulation Of Tyrosine Phosphorylation Of Stat1 Protein
  • Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
  • Protein Ubiquitination
  • Regulation Of Activation Of Jak2 Kinase Activity
  • Regulation Of Cytokine Secretion
  • Regulation Of Growth
  • Regulation Of Interferon-Gamma-Mediated Signaling Pathway
  • Regulation Of Protein Phosphorylation
  • Response To Estradiol
  • Response To Lipopolysaccharide
  • Response To Peptide Hormone
  • Response To Progesterone
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_11448| AS27_15099| AS28_14481| cis1| CISH1| Cish7| cytokine inducible SH2-containing protein 1| cytokine inducible SH2-containing protein 7| cytokine-inducible SH2 protein 1| D623_10019162| GW7_04738| GW7_15638| H920_17602| I79_002134| jab| JAK2-binding protein| JAK binding protein| M959_02443| N301_01349| N302_11696| N303_11892| N305_02920| N306_05520| N307_08124| N308_08937| N310_13279| N312_00362| N320_10810| N321_11176| N322_00916| N324_10300| N325_08912| N326_13320| N327_10617| N328_11968| N329_06223| N330_11376| N331_05503| N333_02579| N335_03073| N336_06474| N339_02832| N340_10625| N341_02730| PAL_GLEAN10009699| PANDA_011680| SOCS-1| socs1-a| socs1-b| ssi-1| SSI1| STAT induced SH3 protein 1| STAT-induced STAT inhibitor 1| suppressor of cytokine signaling 1-like protein| Tec-interacting protein 3| TIP3| TIP-3| UY3_05453| Y1Q_005495| Y956_05223| Z169_02509| socs1

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