The Function of SOCS1
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
Protein names
Recommended name:
Suppressor of cytokine signaling 1Short name:
JABAlternative name(s):
SOCS-1JAK-binding protein
STAT-induced STAT inhibitor 1
SSI-1
Tec-interacting protein 3
TIP-3
Top Gene-Substance Interactions
SOCS1 Interacts with These Diseases
| Disease | Score |
Substances That Increase SOCS1
| Substances | Interaction | Organism | Category |
Substances That Decrease SOCS1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.
Gene Pathways:
Induction:
By a subset of cytokines including those belonging to the interferon, interleukin and colony-stimulating factor families.
Molecular Function:
- Protein Kinase Inhibitor Activity
- Insulin-Like Growth Factor Receptor Binding
- Kinase Inhibitor Activity
- Protein Kinase Binding
Biological Processes:
- Regulation Of Protein Phosphorylation
- Jak-Stat Cascade
- Regulation Of Activation Of Jak2 Kinase Activity
- Protein Ubiquitination
- Cytokine-Mediated Signaling Pathway
- Response To Estradiol
- Response To Lipopolysaccharide
- Response To Progesterone
- Regulation Of Growth
- Negative Regulation Of Tyrosine Phosphorylation Of Stat1 Protein
- Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
- Response To Peptide Hormone
- Fat Cell Differentiation
- Negative Regulation Of Jak-Stat Cascade
- Negative Regulation Of Insulin Receptor Signaling Pathway
- Regulation Of Cytokine Secretion
- Regulation Of Interferon-Gamma-Mediated Signaling Pathway
- Cellular Response To Amino Acid Stimulus