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  3. SOAT1

SOAT1 (Sterol O-acyltransferase 1)

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The Function of SOAT1

Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase.

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Protein names

Recommended name:

Sterol O-acyltransferase 1

Short name:

ACAT-1

Alternative name(s):

Acyl-coenzyme A:cholesterol acyltransferase 1
Cholesterol acyltransferase 1

SOAT1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1044925 (SOAT1) ??

Top Gene-Substance Interactions

Substances That Increase SOAT1

Substances Interaction Organism Category

Substances That Decrease SOAT1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • HNF-1A
  • STAT3
  • HNF-1
  • C/EBPbeta
  • STAT5B
  • IRF-1
  • STAT1
  • STAT1beta
  • STAT1alpha
  • TFIID

Gene Pathways:

  • Steroid biosynthesis

Induction:

Highly activated by the presence of cholesterol.

Molecular Function:

  • Cholesterol Binding
  • Cholesterol O-Acyltransferase Activity
  • Fatty-Acyl-Coa Binding
  • Sterol O-Acyltransferase Activity

Biological Processes:

  • Cholesterol Efflux
  • Cholesterol Esterification
  • Cholesterol Homeostasis
  • Cholesterol Metabolic Process
  • Cholesterol Storage
  • Macrophage Derived Foam Cell Differentiation
  • Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process
  • Very-Low-Density Lipoprotein Particle Assembly

Drug Bank:

  • Ezetimibe
  • Hesperetin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ACAT| acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase)| A306_15362| ACACT| ACAT1| ACAT-1| acetyl-CoA acetyltransferase 1| acyl-CoA:cholesterol acyltransferase| acyl-CoA:cholesterol acyltransferase 1| Acyl-coenzyme A:cholesterol acyltransferase 1| acyltransferase wax synthase| adrenocortical lipid depletion| ald| AS27_08149| AS28_09979| Axonemal dynein light chain domain-containing protein 1| cholesterol acyltransferase 1| H920_07922| hid| I79_015159| M959_08578| MDA_GLEAN10016476| N300_02661| N301_09713| N302_11234| N307_04675| N310_02936| N311_02595| N312_08029| N320_00820| N321_13060| N322_10197| N324_09034| N326_07331| N328_06812| N329_06454| N330_04479| N331_06104| N332_06125| N333_11348| N335_03373| N336_01124| N339_09897| N340_01076| N341_07178| PANDA_004304| Putative elongation factor 1-alpha-like 3| putative Soat1-prov protein| SOAT| STAT| sterol O-acyltransferase 1-like protein| sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1| TREES_T100015799| Y1Q_004343| Y956_06439| Z169_13415| soat1

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