The Function of SOAT1
Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase.
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Protein names
Recommended name:
Sterol O-acyltransferase 1Short name:
ACAT-1Alternative name(s):
Acyl-coenzyme A:cholesterol acyltransferase 1Cholesterol acyltransferase 1
- RS1044925 (SOAT1) ??
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Top Gene-Substance Interactions
Substances That Increase SOAT1
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Substances That Decrease SOAT1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
Highly activated by the presence of cholesterol.
Molecular Function:
- Fatty-Acyl-Coa Binding
- Sterol O-Acyltransferase Activity
- Cholesterol Binding
- Cholesterol O-Acyltransferase Activity
Biological Processes:
- Cholesterol Metabolic Process
- Macrophage Derived Foam Cell Differentiation
- Cholesterol Storage
- Cholesterol Efflux
- Very-Low-Density Lipoprotein Particle Assembly
- Cholesterol Esterification
- Cholesterol Homeostasis
- Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process