The Function of SNRPD3
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing.
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Protein names
Recommended name:
Small nuclear ribonucleoprotein Sm D3Alternative name(s):
Sm-D3snRNP core protein D3
Top Gene-Substance Interactions
SNRPD3 Interacts with These Diseases
| Disease | Score |
Substances That Increase SNRPD3
| Substances | Interaction | Organism | Category |
Substances That Decrease SNRPD3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Enzyme Binding
- U2 Snrna Binding
- Poly(A) Rna Binding
- Telomerase Rna Binding
- Histone Pre-Mrna Dcp Binding
- U7 Snrna Binding
- U1 Snrnp Binding
Biological Processes:
- Spliceosomal Complex Assembly
- Spliceosomal Snrnp Assembly
- Mrna Splicing, Via Spliceosome
- Termination Of Rna Polymerase Ii Transcription
- Protein Methylation
- Histone Mrna Metabolic Process
- Rna Splicing
- Nuclear Import