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  3. SNAP25

SNAP25 (Synaptosome associated protein 25)

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Summary of SNAP25

Synaptosomal-associated protein 25 (SNAP-25) plays a crucial role in the release of neurotransmitters (from presynapse- excocytosis) (R, R2). It plays a crucial role in the targeting, docking and fusion of intracellular vesicles with the plasma membrane (R). 

SNAP-25 plays a crucial role in the release of neurotransmitters such as noradrenaline and serotonin from presynapses (R,R2,R3). 

SNAP-25 is also important for insulin secretion, and inhibition of SNAP-25 function dramatically decreases the insulin secretion (R).
Mutations in this gene are associated with epilepsy and intellectual disabilities (G>A)  [R]  
It's better to have this gene increased most of the time.
0 users want this gene increased, 0 users want it decreased

The Function of SNAP25

t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.

Protein names

Recommended name:

Synaptosomal-associated protein 25

Short name:

SUP

Alternative name(s):

SNAP-25
Super protein
Synaptosomal-associated 25 kDa protein

SNAP25 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1051312 (SNAP25) ??
  2. RS116940963 (SNAP25) ??
  3. RS362584 (SNAP25) ??
  4. RS362987 (SNAP25) ??
  5. RS362988 (SNAP25) ??
  6. RS362998 (SNAP25) ??
  7. RS363039 (SNAP25) ??
  8. RS363043 (SNAP25) ??
  9. RS363050 (SNAP25) ??
  10. RS3746544 (SNAP25) ??
  11. RS3787283 (SNAP25) ??
  12. RS8636 (SNAP25) ??

Top Gene-Substance Interactions

SNAP25 Interacts with These Diseases

Disease Score

Fixes

The following are the best ways to increase SNAP25:

  • Exercise (R)
  • Epicatechins (R)

Chocolate is the richest source of epicatechins. Epicatechins are also high in apples, blackberries, broad beans, cherries, black grapes, pears, raspberries.

Substances That Increase SNAP25

Substances Interaction Organism Category

Substances That Decrease SNAP25

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Myasthenic syndrome, congenital, 18From UniProt: Myasthenic syndrome, congenital, 18 (CMS18): A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS18 is an autosomal dominant presynaptic disorder clinically characterized by early-onset muscle weakness and easy fatigability associated with delayed psychomotor development and ataxia. [MIM:616330]

     From NCBI Gene: Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008] From UniProt: t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • AP-1
  • AhR
  • c-Jun
  • STAT3
  • NF-kappaB1
  • STAT5A

Tissue specificity:

Neurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei, and granule cells of the cerebellum.

Gene Pathways:

  • Metabolism
  • Disease
  • Neuronal System
  • SNARE interactions in vesicular transport

Molecular Function:

  • Calcium-Dependent Protein Binding
  • Snap Receptor Activity
  • Syntaxin-1 Binding

Biological Processes:

  • Associative Learning
  • Chemical Synaptic Transmission
  • Glutamate Secretion
  • Locomotory Behavior
  • Long-Term Synaptic Potentiation
  • Neurotransmitter Secretion
  • Neurotransmitter Uptake
  • Regulation Of Insulin Secretion
  • Regulation Of Neuron Projection Development
  • Synaptic Vesicle Docking
  • Synaptic Vesicle Exocytosis
  • Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane
  • Synaptic Vesicle Priming

Drug Bank:

  • Botulinum Toxin Type A
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| SUP| AS27_11327| AS28_01665| bA416N4.2| Bdr| blind drunk| CB1_000951004| CG40452 gene product from transcript CG40452-RA| CG40452-PA| CG40452-PC| CMS18| D623_10032296| dJ1068F16.2| Dmel_CG40452| EGK_02665| GENA70| GW7_07258| H920_20231| I79_000431| M959_07821| N300_06367| N301_10995| N302_14355| N303_01216| N305_03533| N306_06622| N307_05874| N308_11924| N309_08116| N310_07498| N311_11692| N312_03089| N320_07740| N321_05537| N322_02127| N324_03018| N325_07732| N326_11609| N327_00823| N328_12043| N329_01669| N330_12077| N331_02666| N332_10435| N333_10999| N334_00675| N335_02279| N336_11119| N339_06507| N340_05607| N341_12690| PANDA_007296| resistance to inhibitors of cholinesterase 4 homolog| ric4| RIC-4| SEC9| SNAP| snap-25| SNAP-25a| SNAP-25B| Snap25-PA| Snap25-PC| snp25| sp| super protein| synapse protein 25| synaptosomal-associated 25 kDa protein| synaptosomal-associated 25kD protein| synaptosomal-associated protein| Synaptosomal-associated protein 25| synaptosomal-associated protein 25 isoform SNAP25A| synaptosomal-associated protein 25 isoform SNAP25B| synaptosomal-associated protein, 25kDa| synaptosomal-associated protein, 25 kDa| Synaptosomal-associated protein 25kDa| synaptosomal-associated protein 25-like| synaptosome associated protein 25kDa| TREES_T100009912| Y1Q_004118| Y956_14543| Z169_10198| snap25

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