The Function of SNAI2
Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.
Protein names
Recommended name:
Zinc finger protein SNAI2Alternative name(s):
Neural crest transcription factor SlugProtein snail homolog 2
- RS12155623 (SNAI2) ??
- RS17641971 (SNAI2) ??
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Top Gene-Substance Interactions
SNAI2 Interacts with These Diseases
| Disease | Score |
Substances That Increase SNAI2
| Substances | Interaction | Organism | Category |
Substances That Decrease SNAI2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in most adult human tissues, including spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not detected in peripheral blood leukocyte. Expressed in the dermis and in all layers of the epidermis, with high levels of expression in the basal layers (at protein level). Expressed in osteoblasts (at protein level). Expressed in mesenchymal stem cells (at protein level). Expressed in breast tumor cells (at protein level).
Gene Pathways:
Molecular Function:
- Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Chromatin Binding
- Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
- Sequence-Specific Dna Binding
- Metal Ion Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Osteoblast Differentiation
- Epithelial To Mesenchymal Transition
- Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
- Cell Migration Involved In Endocardial Cushion Formation
- Transcription, Dna-Templated
- Negative Regulation Of Cell Adhesion Involved In Substrate-Bound Cell Migration
- Notch Signaling Pathway
- Sensory Perception Of Sound
- Negative Regulation Of Keratinocyte Proliferation
- Negative Regulation Of Vitamin D Biosynthetic Process
- Neural Crest Cell Development
- Positive Regulation Of Cell Migration
- Negative Regulation Of Chondrocyte Differentiation
- Regulation Of Chemokine Production
- Negative Regulation Of Cell Adhesion Mediated By Integrin
- Positive Regulation Of Histone Acetylation
- Negative Regulation Of Catenin Import Into Nucleus
- Desmosome Disassembly
- Pigmentation
- Negative Regulation Of Dna Damage Response, Signal Transduction By P53 Class Mediator
- Cellular Response To Fibroblast Growth Factor Stimulus
- Positive Regulation Of Fat Cell Differentiation
- Regulation Of Osteoblast Differentiation
- White Fat Cell Differentiation
- Palate Development
- Canonical Wnt Signaling Pathway
- Epithelium Development
- Cartilage Morphogenesis
- Regulation Of Branching Involved In Salivary Gland Morphogenesis
- Negative Regulation Of Vitamin D Receptor Signaling Pathway
- Cellular Response To Epidermal Growth Factor Stimulus
- Cellular Response To Ionizing Radiation
- Negative Regulation Of Canonical Wnt Signaling Pathway
- Negative Regulation Of Cell-Cell Adhesion By Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Dna Damage
- Negative Regulation Of Stem Cell Proliferation
- Regulation Of Bicellular Tight Junction Assembly
- Negative Regulation Of Anoikis
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand