The Function of SNAI1
Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
Protein names
Recommended name:
Zinc finger protein SNAI1Alternative name(s):
Protein snail homolog 1Protein sna
- RS11697848 (SNAI1) ??
- RS6020157 (SNAI1) ??
- RS7352944 (SNAI1) ??
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Top Gene-Substance Interactions
SNAI1 Interacts with These Diseases
| Disease | Score |
Substances That Increase SNAI1
| Substances | Interaction | Organism | Category |
Substances That Decrease SNAI1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines.
Gene Pathways:
Induction:
Induced by TPA maximally by 2.5-fold at 4 hours, in HepG2 cells (at protein level).
Caution:
The interaction with mouse KPNA2 may prevent SNAI1 nuclear import.
Molecular Function:
- Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
- Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Kinase Binding
- Metal Ion Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Osteoblast Differentiation
- Mesoderm Formation
- Epithelial To Mesenchymal Transition
- Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
- Positive Regulation Of Epithelial To Mesenchymal Transition
- Negative Regulation Of Vitamin D Biosynthetic Process
- Positive Regulation Of Cell Migration
- Hair Follicle Morphogenesis
- Negative Regulation Of Dna Damage Response, Signal Transduction By P53 Class Mediator
- Positive Regulation Of Transcription, Dna-Templated
- Palate Development
- Cartilage Morphogenesis
- Trophoblast Giant Cell Differentiation
- Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development
- Left/Right Pattern Formation
- Notch Signaling Involved In Heart Development
- Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Dna Damage
- Regulation Of Bicellular Tight Junction Assembly