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  3. SNAI1

SNAI1 (Snail family transcriptional repressor 1)

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The Function of SNAI1

Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.

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Protein names

Recommended name:

Zinc finger protein SNAI1

Alternative name(s):

Protein snail homolog 1
Protein sna

SNAI1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11697848 (SNAI1) ??
  2. RS6020157 (SNAI1) ??
  3. RS7352944 (SNAI1) ??

Top Gene-Substance Interactions

SNAI1 Interacts with These Diseases

Disease Score

Substances That Increase SNAI1

Substances Interaction Organism Category

Substances That Decrease SNAI1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • c-Jun
  • AREB6

Tissue specificity:

Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines.

Gene Pathways:

  • Adherens junction

Induction:

Induced by TPA maximally by 2.5-fold at 4 hours, in HepG2 cells (at protein level).

Caution:

The interaction with mouse KPNA2 may prevent SNAI1 nuclear import.

Molecular Function:

  • Kinase Binding
  • Metal Ion Binding
  • Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
  • Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding

Biological Processes:

  • Cartilage Morphogenesis
  • Epithelial To Mesenchymal Transition
  • Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
  • Hair Follicle Morphogenesis
  • Left/Right Pattern Formation
  • Mesoderm Formation
  • Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development
  • Negative Regulation Of Dna Damage Response, Signal Transduction By P53 Class Mediator
  • Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Dna Damage
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Negative Regulation Of Vitamin D Biosynthetic Process
  • Notch Signaling Involved In Heart Development
  • Osteoblast Differentiation
  • Palate Development
  • Positive Regulation Of Cell Migration
  • Positive Regulation Of Epithelial To Mesenchymal Transition
  • Positive Regulation Of Transcription, Dna-Templated
  • Regulation Of Bicellular Tight Junction Assembly
  • Trophoblast Giant Cell Differentiation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_00256| AS27_03241| AS28_06946| dJ710H13.1| EGK_02302| GW7_16442| MDA_GLEAN10010587| N300_03253| N301_06081| N302_00428| N303_02919| N305_05870| N306_01669| N307_09895| N309_13142| PAL_GLEAN10024469| PANDA_000799| protein sna| protein snail homolog 1| Protein snail-like protein 1| Protein snail like protein Sna| Protein snail Sna| SLUGH2| SNA| Sna1| SNAH| snail| snail1| snail 1 homolog| snail 1 zinc finger protein| snail family zinc finger 1| snail homolog 1| snail homolog 1 (Drosophila)| snail like protein| snail-like protein 1| SNAIL-like zinc finger protein| xSna| Xsnail| Y956_12904| Z169_03725| Zinc finger protein SNAI1| zinc finger protein SNAI1-like protein| snai1

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