The Function of SMC5
Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).
Protein names
Recommended name:
Structural maintenance of chromosomes protein 5Short name:
SMC-5Alternative name(s):
SMC protein 5hSMC5
- RS11142387 (SMC5) ??
- RS13034723 (SMC5) ??
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Top Gene-Substance Interactions
Substances That Increase SMC5
| Substances | Interaction | Organism | Category |
Substances That Decrease SMC5
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed (PubMed:11408570). Strongly expressed in testis (PubMed:11408570).
Molecular Function:
Biological Processes:
- Telomere Maintenance Via Recombination
- Double-Strand Break Repair Via Homologous Recombination
- Cellular Response To Dna Damage Stimulus
- Sister Chromatid Cohesion
- Mitotic Nuclear Division
- Protein Sumoylation
- Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion
- Cell Division
- Positive Regulation Of Chromosome Segregation
- Resolution Of Recombination Intermediates
- Cellular Senescence