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  3. SMC5

SMC5 (Structural maintenance of chromosomes 5)

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The Function of SMC5

Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).

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Protein names

Recommended name:

Structural maintenance of chromosomes protein 5

Short name:

SMC-5

Alternative name(s):

SMC protein 5
hSMC5

SMC5 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11142387 (SMC5) ??
  2. RS13034723 (SMC5) ??

Top Gene-Substance Interactions

Substances That Increase SMC5

Substances Interaction Organism Category

Substances That Decrease SMC5

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • GATA-1
  • Cdc5
  • Lmo2

Tissue specificity:

Widely expressed (PubMed:11408570). Strongly expressed in testis (PubMed:11408570).

Molecular Function:

  • Atp Binding

Biological Processes:

  • Cell Division
  • Cellular Response To Dna Damage Stimulus
  • Cellular Senescence
  • Double-Strand Break Repair Via Homologous Recombination
  • Mitotic Nuclear Division
  • Positive Regulation Of Chromosome Segregation
  • Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion
  • Protein Sumoylation
  • Resolution Of Recombination Intermediates
  • Sister Chromatid Cohesion
  • Telomere Maintenance Via Recombination
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| MAM domain-containing protein 2| AAF51749| CG32438 gene product from transcript CG32438-RF| CG32438-PE| CG32438-PF| CG32438-PG| CG32438-PH| D623_10034439| Dmel_CG32438| DmSMC5| hSMC5| I79_022532| M91_01887| MDA_GLEAN10017996| MLZ-453| mSMC5| N303_10540| N306_02617| N320_00842| N324_06587| N328_01498| PAL_GLEAN10021084| protein expressed in male leptotene and zygotene spermatocytes 453| SMC-5| Smc5l1| SMC5-PE| SMC5-PF| SMC5-PG| SMC5-PH| SMC5 structural maintenance of chromosomes 5-like 1| SMC protein 5| structural maintenance of chromosomes protein 5| Structural maintenance of chromosomes protein 5-like protein| TREES_T100010043| Y1Q_006171| smc5

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