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  3. SMC2

SMC2 (Structural maintenance of chromosomes 2)

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The Function of SMC2

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

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Protein names

Recommended name:

Structural maintenance of chromosomes protein 2

Short name:

SMC-2

Alternative name(s):

SMC protein 2
Chromosome-associated protein E
hCAP-E
XCAP-E homolog

SMC2 SNPs

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  1. RS1450679 (SMC2) ??

Top Gene-Substance Interactions

SMC2 Interacts with These Diseases

Disease Score

Substances That Increase SMC2

Substances Interaction Organism Category

Substances That Decrease SMC2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • AhR
  • c-Jun
  • c-Fos

Molecular Function:

  • Atp Binding
  • Protein Heterodimerization Activity

Biological Processes:

  • Cell Division
  • Kinetochore Organization
  • Meiotic Chromosome Condensation
  • Meiotic Chromosome Segregation
  • Mitotic Chromosome Condensation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_15536| AAF58197| Anapl_13318| CAPE| CAP-E| CB1_000807002| CG10212 gene product from transcript CG10212-RA| CG10212-PA| chromosome-associated protein E| chromosome scaffold protein ScII| D623_10031608| Dmel_CG10212| DmSMC2| dSMC2| fb92e05| FGF-inducible protein 16| fibroblast growth factor inducible 16| Fin16| GW7_10999| H920_19519| I79_001128| MDA_GLEAN10008889| N309_07874| N335_00098| N339_03164| PAL_GLEAN10009375| PANDA_014755| SCII| smc-2| SMC2L1| SMC2-PA| SMC2 structural maintenance of chromosomes 2-like 1| SMC2 (structural maintenance of chromosomes 2, yeast)-like 1| SMC protein 2| structural maintenance of chromosomes 2-like 1| structural maintenance of chromosomes protein 1A-like protein| structural maintenance of chromosomes protein 2| Structural maintenance of chromosomes protein 2-like protein| structural maintenance of chromosomes (SMC) family member, chromosome-associated protein E| XCAP-E homolog| xsmc2| Y1Q_003014| zeh1628| smc2

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