The Function of SMC2
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
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Protein names
Recommended name:
Structural maintenance of chromosomes protein 2Short name:
SMC-2Alternative name(s):
SMC protein 2Chromosome-associated protein E
hCAP-E
XCAP-E homolog
- RS1450679 (SMC2) ??
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Top Gene-Substance Interactions
SMC2 Interacts with These Diseases
| Disease | Score |
Substances That Increase SMC2
| Substances | Interaction | Organism | Category |
Substances That Decrease SMC2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Molecular Function:
Biological Processes:
- Mitotic Chromosome Condensation
- Meiotic Chromosome Condensation
- Meiotic Chromosome Segregation
- Cell Division
- Kinetochore Organization