The Function of SMARCE1
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by Swi/Snf complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells.
Protein names
Recommended name:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1Short name:
BAF57Alternative name(s):
BRG1-associated factor 57- RS7221109 (SMARCE1) ??
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Top Gene-Substance Interactions
Substances That Increase SMARCE1
Substances | Interaction | Organism | Category |
Substances That Decrease SMARCE1
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Chromatin Binding
- Dna Binding
- Ligand-Dependent Nuclear Receptor Binding
- N-Acetyltransferase Activity
- Protein N-Terminus Binding
- Rna Binding
- Transcription Coactivator Activity
Biological Processes:
- Atp-Dependent Chromatin Remodeling
- Covalent Chromatin Modification
- Chromatin Remodeling
- Negative Regulation Of Transcription, Dna-Templated
- Neurogenesis
- Nucleosome Disassembly
- Regulation Of Transcription From Rna Polymerase Ii Promoter