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  3. SMARCE1

SMARCE1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1)

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The Function of SMARCE1

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by Swi/Snf complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells.

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Protein names

Recommended name:

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

Short name:

BAF57

Alternative name(s):

BRG1-associated factor 57

SMARCE1 SNPs

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  1. RS7221109 (SMARCE1) ??

Top Gene-Substance Interactions

Substances That Increase SMARCE1

Substances Interaction Organism Category

Substances That Decrease SMARCE1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

Gene Pathways:

  • Chromatin organization

Molecular Function:

  • Chromatin Binding
  • Dna Binding
  • Ligand-Dependent Nuclear Receptor Binding
  • N-Acetyltransferase Activity
  • Protein N-Terminus Binding
  • Rna Binding
  • Transcription Coactivator Activity

Biological Processes:

  • Atp-Dependent Chromatin Remodeling
  • Covalent Chromatin Modification
  • Chromatin Remodeling
  • Negative Regulation Of Transcription, Dna-Templated
  • Neurogenesis
  • Nucleosome Disassembly
  • Regulation Of Transcription From Rna Polymerase Ii Promoter
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_14067| Anapl_12189| AS27_11196| AS28_09344| Baf27| BAF57| BRG1-associated factor 57| chromatin remodeling complex BRG1-associated factor 57| CSS5| D623_10030351| fb33d02| fb54d11| I79_025824| M91_05306| N300_06131| N301_03627| N302_08165| N303_00625| N305_13459| N307_01189| N308_14657| N320_08233| N321_08901| N322_03343| N324_10730| N325_11009| N326_00916| N327_05045| N328_09726| N329_06463| N331_05657| N332_14366| N333_07167| N336_02224| PANDA_014411| RGD1304726| SWI/SNF-related matrix-associated actin-dependent regulator chromatin subfamily E member 1| SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1| SWI/SNF related, matrix associated, actin dependent regulator of chromatinE1| SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1| TREES_T100004437| XBaf57| Y1Q_017160| Y956_09855| Z169_13720| smarce1

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