The Function of SMAD1
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.
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Protein names
Recommended name:
Mothers against decapentaplegic homolog 1Short name:
JV4-1Alternative name(s):
MAD homolog 1Mothers against DPP homolog 1
Mad-related protein 1
SMAD family member 1
SMAD 1
Smad1
hSMAD1
Transforming growth factor-beta-signaling protein 1
BSP-1
- RS34132583 (SMAD1) ??
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Top Gene-Substance Interactions
SMAD1 Interacts with These Diseases
| Disease | Score |
Substances That Increase SMAD1
| Substances | Interaction | Organism | Category |
Substances That Decrease SMAD1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitous. Highest expression seen in the heart and skeletal muscle.
Molecular Function:
- Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Core Promoter Sequence-Specific Dna Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Signal Transducer Activity, Downstream Of Receptor
- Protein Kinase Binding
- Transforming Growth Factor Beta Receptor, Pathway-Specific Cytoplasmic Mediator Activity
- Identical Protein Binding
- Metal Ion Binding
- Co-Smad Binding
- I-Smad Binding
- Primary Mirna Binding
Biological Processes:
- Mapk Cascade
- Ureteric Bud Development
- Mesodermal Cell Fate Commitment
- Osteoblast Fate Commitment
- Inflammatory Response
- Signal Transduction
- Transforming Growth Factor Beta Receptor Signaling Pathway
- Smad Protein Complex Assembly
- Gamete Generation
- Negative Regulation Of Cell Proliferation
- Embryonic Pattern Specification
- Positive Regulation Of Gene Expression
- Bmp Signaling Pathway
- Midbrain Development
- Hindbrain Development
- Primary Mirna Processing
- Homeostatic Process
- Positive Regulation Of Osteoblast Differentiation
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Cartilage Development
- Cardiac Muscle Cell Proliferation
- Bone Development
- Smad Protein Signal Transduction
- Positive Regulation Of Cartilage Development
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter Involved In Cellular Response To Chemical Stimulus
- Positive Regulation Of Pri-Mirna Transcription From Rna Polymerase Ii Promoter