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  3. SMAD1

SMAD1 (SMAD family member 1)

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The Function of SMAD1

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.

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Protein names

Recommended name:

Mothers against decapentaplegic homolog 1

Short name:

JV4-1

Alternative name(s):

MAD homolog 1
Mothers against DPP homolog 1
Mad-related protein 1
SMAD family member 1
SMAD 1
Smad1
hSMAD1
Transforming growth factor-beta-signaling protein 1
BSP-1

SMAD1 SNPs

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  1. RS34132583 (SMAD1) ??

Top Gene-Substance Interactions

SMAD1 Interacts with These Diseases

Disease Score

Substances That Increase SMAD1

Substances Interaction Organism Category

Substances That Decrease SMAD1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • NF-kappaB1
  • Nkx2-5
  • C/EBPalpha
  • Sox9
  • p300

Tissue specificity:

Ubiquitous. Highest expression seen in the heart and skeletal muscle.

Molecular Function:

  • Co-Smad Binding
  • Identical Protein Binding
  • I-Smad Binding
  • Metal Ion Binding
  • Primary Mirna Binding
  • Protein Kinase Binding
  • Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
  • Rna Polymerase Ii Core Promoter Sequence-Specific Dna Binding
  • Signal Transducer Activity, Downstream Of Receptor
  • Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Transforming Growth Factor Beta Receptor, Pathway-Specific Cytoplasmic Mediator Activity

Biological Processes:

  • Bmp Signaling Pathway
  • Bone Development
  • Cardiac Muscle Cell Proliferation
  • Cartilage Development
  • Embryonic Pattern Specification
  • Gamete Generation
  • Hindbrain Development
  • Homeostatic Process
  • Inflammatory Response
  • Mapk Cascade
  • Mesodermal Cell Fate Commitment
  • Midbrain Development
  • Negative Regulation Of Cell Proliferation
  • Osteoblast Fate Commitment
  • Positive Regulation Of Cartilage Development
  • Positive Regulation Of Gene Expression
  • Positive Regulation Of Osteoblast Differentiation
  • Positive Regulation Of Pri-Mirna Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter Involved In Cellular Response To Chemical Stimulus
  • Primary Mirna Processing
  • Signal Transduction
  • Smad Protein Complex Assembly
  • Smad Protein Signal Transduction
  • Transforming Growth Factor Beta Receptor Signaling Pathway
  • Ureteric Bud Development
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| MLP| AS27_05760| AS28_13045| BMP pathway effector| BMP signal transducer Smad1| BSP1| BSP-1| CB1_000961016| dwarfin-A| dwf-A| EGK_16135| fb39h09| GW7_19041| H920_18045| I79_007040| jv4-1| JV41| M91_06511| M959_05140| Madh1| MAD homolog 1| MAD homolog1 (mothers against decapentaplegic, Drosophila)| MAD (mothers against decapentaplegic, Drosophila) homolog 1| MAD, mothers against decapentaplegic homolog 1| MADR1| mad-related protein 1| MDA_GLEAN10015177| Mlp1| mMad1| Mothers against decapentaplegic 1| mothers against decapentaplegic 1-like protein| Mothers against decapentaplegic 1 (SMAD 1) isoform 3-like protein| Mothers against decapentaplegic homolog 1| Mothers against decapentaplegic-like 1| mothers against decapentaplegic-like 1-like protein| mothers against decapentaplegic-like protein 1| Mothers against decapentaplegic like protein 1| mothers against DPP homolog 1| mothers-against-DPP-related 1| MusMLP| N300_03053| N301_03927| N302_06096| N303_11746| N306_02015| N307_06964| N308_06531| N309_07320| N310_13851| N311_03519| N320_02041| N321_09712| N322_05654| N324_08170| N326_09506| N327_12633| N328_09409| N330_12741| N333_12220| N334_08860| N335_00896| N336_04743| N340_01817| N341_03869| PAL_GLEAN10016624| PANDA_004345| Sma- and Mad-related protein 1| smad-1| Smad 1| smad1-a| smad1-b| SMAD, mothers against DPP homolog 1| TGF-beta signaling protein 1| transforming growth factor-beta signaling protein 1| TREES_T100000289| XMad| Xmad1| Xsmad1| Y1Q_027642| Y956_01812| smad1

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