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  3. SLIT3

SLIT3 (Slit guidance ligand 3)

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The Function of SLIT3

May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.

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Protein names

Recommended name:

Slit homolog 3 protein

Alternative name(s):

Slit-3
Multiple epidermal growth factor-like domains protein 5
Multiple EGF-like domains protein 5

SLIT3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12188351 (SLIT3) ??
  2. RS2974438 (SLIT3) ??
  3. RS4282339 (SLIT3) ??
  4. RS6555855 (SLIT3) ??

Top Gene-Substance Interactions

Substances That Increase SLIT3

Substances Interaction Organism Category

Substances That Decrease SLIT3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • C/EBPbeta
  • HNF-4alpha1
  • HNF-4alpha2
  • HNF-3beta

Tissue specificity:

Predominantly expressed in thyroid.

Gene Pathways:

  • Axon guidance

Molecular Function:

  • Calcium Ion Binding
  • Heparin Binding
  • Roundabout Binding

Biological Processes:

  • Animal Organ Morphogenesis
  • Apoptotic Process Involved In Luteolysis
  • Axon Extension Involved In Axon Guidance
  • Axon Guidance
  • Cellular Response To Hormone Stimulus
  • Negative Chemotaxis
  • Negative Regulation Of Cell Growth
  • Negative Regulation Of Cell Proliferation
  • Negative Regulation Of Chemokine-Mediated Signaling Pathway
  • Negative Regulation Of Gene Expression
  • Regulation Of Axonogenesis
  • Response To Cortisol
  • Roundabout Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| slit homolog 3| slit-like protein 3| slit2| A306_14646| AS27_11847| AS28_10311| b2b2362.1Clo| CB1_002798003| D623_10034891| H920_04474| I79_001955| M91_03244| M959_08274| Megf5| multiple EGF-like domains protein 5| multiple epidermal growth factor-like domains 5| multiple epidermal growth factor-like domains protein 5| N300_15918| N301_00813| N302_07133| N303_06645| N305_02454| N306_11046| N307_12679| N308_13108| N309_12117| N310_09547| N328_01941| N340_10886| PAL_GLEAN10018862| PANDA_007155| Slil2| Slit1| slit-3| Slit 3 protein| slit 3 protein-like protein| slit homolog 3 (Drosophila)| slit homolog 3 protein| slit homolog 3 protein-like| Slit-like 3 protein| Slit like protein 3 protein| Slit-like protein 3 protein| TREES_T100014793| UY3_18197| Y1Q_021263| Y956_14135| Z169_16462| slit3

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